Invention:
This technology is a laparoscope that combines both white light and fluorescence imaging (WLFI) for wide field tumor localization and multiphoton microscopy (MPM) for microscopic surgical margin definition. The WLFI channel and MPM imaging channel are housed on an extendable arm on the laparoscope and images from both channels are displayed simultaneously on a computer via cable connection. These images are then analyzed by software using machine learning algorithms to determine probability of tissue being diseased in real time.
Background:
Laparoscopic surgeries are minimally invasive surgical procedures that allow for surgeons to gain a better view of the abdomen. Imaging techniques can improve this view by giving wider field tumor localization as well as surgical margin definition. This invention incorporates such imaging techniques to improve the intraoperative surgical guidance in the resection of tumors and can be modified for other surgeries by adjusting fluorescence properties for specific tissues involved. With the inclusion of these optical features, the device surpasses current commercial laparoscopes by providing better resolution with higher sensitivity and specificity.
Applications:
- Intraoperative guidance for tumor resection
- Examine resected tissue outside the body
Advantages:
- Novel inclusion of MPM
- Better resolution
- High sensitivity and specificity
- Real time tissue analysis
