Miniature Multispectral Fluorescence Imaging and Cell Collection Probe for Longitudinal In Vivo Tumor Characterization and Growth Assessment in Animal Models of Cancer

Case ID:
UA22-033
Invention:

This technology is a miniature endoscopic probe that can conduct fluorescence imaging at multiple different wavelengths and collect cell samples, all encapsulated in a single probe. Because of the design of the probe, it does not require withdrawal and reinsertion to change filters or devices. It is particularly useful in examination and assessment of cancerous tumors in small living animals. The probe is also designed such that it could be implemented through the working channel of standard gastroscopes for human patients.

Background:
This invention is primarily designed to help improve research and assessment of human cancers in animal models. Historically, examining progression of cancer in animal models for the purposes of cancer research required euthanasia to access the tissue. But now, techniques are being adopted that allow live examination. However, there is a need for developing efficient endoscopy techniques that are small enough to work with small animals such as mice. This technology provides an all-in-one solution to examine cancerous cells in multiple fluorescence wavelengths and collect cell samples, all in a small package that works with small animals.

In addition to the use in cancer research, this invention could be applied to any application where there is limited space and fluorescence imaging is valuable, especially with multiple excitation / emission wavelengths.

Applications:

  • Cancer detection
  • Cancer research
  • Fluorescence imaging in small spaces


Advantages:

  • Can detect a variety of fluorescence wavelengths without the need to remove the endoscope to change filters
  • Includes cell collection capability in the same probe
Patent Information:
Contact For More Information:
Jace Langen
Licensing Manager
The University of Arizona
JaceL@tla.arizona.edu
Lead Inventor(s):
Travis Sawyer
Bridget Slomka
Keywords: