Invention:
UA21-131 and UA21-132 Two Patents Pending for SYSTEMS AND METHODS FOR GENERATING AND ANALYZING A CUSTOMIZED GENOMIC SEQUENCE FOR THERAPEUTIC APPLICATIONS
Software: Proof of concept software funded by Tech Launch Arizona developed by a software company is fully functional and creates consistent accurate results.
MAXX Py
The MAXX.py script generates a customized reference genome and an accompanying mutation index file based on a user’s input of mutations, reference genome, and gtf file. Customized reference genomes have been shown to improve alignment of next generation sequencing reads that contain a predefined indel mutation. This capability to increase alignment sensitivity of predefined mutations can potentially be used to improve detection of circulating cancer cells and enhance personalized therapeutic approaches for cancer patients.
MAXX Fusion
The MAXX_Fusion.py script generates a customized reference genome and an accompanying gene fusion index file based on a user’s input of gene fusions, reference genome, and gtf file. Customized reference genomes have been shown to improve alignment of next generation sequencing reads that contain a predefined gene fusion. This capability to increase alignment sensitivity of predefined gene fusions can potentially be used to improve detection of circulating cancer cells and enhance personalized therapeutic approaches for cancer patients.
Applications:
- Cancer diagnostics
- Cancer therapeutics
- Customized therapeutics
- Next generation sequencing
Advantages:
- Software for improved detection of genetic mutations
