Rapid Formation of Polymer Frits in Fused Silica Capillaries Using Spatially-Defined Thermal Polymerization

Case ID:

This invention is a novel method of synthesizing porous polymer frits for capillary liquid chromatography using thermal polymerization. This method provides an alternative to current state-of-the art UV cured polymer frits.


The rapid increase in quality control, research, and drug discovery labs has driven the high performance liquid chromatography/ulta performance liquid chromatography (HPLC/UPLC) market. In addition, most pharmaceutical and biotech firms now opt for UHPLC systems. At this time the inventors have demonstrated the use and efficiency of this invention in conditions similar to those that typically call for UV-polymerized frits.



  • Research settings  


  • Does not require expensive equipment
  • Polymerization is complete in less than 2 minutes
  • Withstands pressure and allows separation of analytes similar to those of UV-cured polymer frits
  • Safer for the capillary system
  • Lowers the cost barrier for liquid chromatography methods
  • Opens research avenues
Patent Information:
Contact For More Information:
Jonathan Larson
Senior Licensing Manager, College of Science
The University of Arizona
Lead Inventor(s):
Craig Aspinwall
Kendall Sandy
Christopher Baker
Elyssia Gallagher
Boying Liang