Practical Synthesis of C-1 Deuterated 3‑Formylindoles by Organo-photoredox Catalyzed Direct Formylation of Indoles with Deuterated Glyoxylic Acid

Case ID:

This innovation is the synthesis of a Carbon-based indole that can be used in the creation of anti-cancer drugs. Indoles are reagents that can also be used in oncological and renal disease treatment. The new method provides a simple protocol that creates differentiated indoles that have a broad functional tolerance. This uses a more cost-effective agent and removes the need for an external light-absorbing catalyst. Specifically, these novel deuterated indoles have versatile structures and can be applied to various types of research. 

There is a lack of cost-effective methods to create deuterated chemicals. These drugs have replaced hydrogen with one of its stable isotopes, deuterium. Deuterated drugs require indoles as their core structure and tend to have a longer half-life. 


  • Anti-cancer drug formulation
  • Renal disease treatment
  • Research tool


  • Organic synthesis
  • Metal-free
  • Simple
  • Synthetically versatile
  • Cost-effective
  • Broad functional tolerance
Patent Information:
Contact For More Information:
Garrett Edmunds
Licensing Manager, UAHS-TLA
The University of Arizona
Lead Inventor(s):
Wei Wang