pH Releasable Linkers for Drug Delivery, Imaging, or Diagnostics

Case ID:

This technology describes water-soluble triazabutadienes as cross-linkers to and protecting groups for small-molecule therapeutics or fluorescent moities. Upon changes in chemical conditions, triazabutadienes release a highly reactive diazonium species, enabling targeted delivery of the cross-linked molecule. 


Cross linking is becoming a valuable practice in chemistry, including for life science applications, with the advent of mass spectrometry. Using cross-linking and "click-chemistry" can enable unique chemical manipulations of linked proteins for various purposes, including drug delivery, diagnostics, and research.  Numerous factors can limit the usefulness of reagents, with solubility and pH being two primary factors.



  • Molecular and tissue diagnostics
  • Clinical microbiology
  • Drug development/release
  • Genomic/proteomic studies
  • Adhesives



  • Adjustable to a wide range of cleavability conditions
  • Adheres under water
  • Can be customized to limit or extend reaction time in presence of water and low pH
  • Uses click chemistry for an easier boding method
Patent Information:
Contact For More Information:
Jonathan Larson
Senior Licensing Manager, College of Science
The University of Arizona
Lead Inventor(s):
John Jewett
Flora Kimani
diagnostic tool