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ERG-7 Inhibitors: Targeting the Sterol Biosynthetic Pathway
This invention relates to small molecule anti-fungal compounds, pharmaceutical compositions, and methods of use for the prevention, treatment, or mitigation of fungal diseases in human and veterinary subjects. In particular aspects, the invention provides inhibitors that modulate fungal sterol biosynthesis, including inhibitors of lanosterol synthase...
Published: 5/6/2026
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Updated: 5/6/2026
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Inventor(s): Rui Xiong, Hongmin Li, Malla Reddy Gannarapu, Divakar Indukuri, Anil Tharappel, Ke Chen, Mengjiao Ma
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Respiratory & Pulmonary, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
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nsP2 Inhibitors: Targeting the Alphavirus nsP2 Protease
This invention relates to antiviral compounds targeting the alphavirus nsP2 protease, pharmaceutical compositions, and methods of use for the prevention, treatment, or mitigation of the Chikungunya virus. This compound selectively interferes with the essential proteolytic processing activity of nsP2, a critical step in the viral life cycle. By blocking...
Published: 4/29/2026
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Updated: 4/29/2026
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Inventor(s): Hongmin Li, Rui Xiong, Subodh Samrat, Malla Reddy Gannarapu, Ran Zhang, Ke Chen, Mengjiao Ma, Omar Alejandro Lozano Ramos, Divakar Indukuri, Renu Bhardwaj
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules
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Novel Multi-Omics Aging Clock
A multi-omics clock analyzes multiple layers of omics data with machine learning to predict remaining lifespan of mammals, particularly for animal model studies. Large omics data sets may be used from combinations of genomics, proteomics, lipids, etc. available from blood or other simple sample collection. This tool can robustly capture changes...
Published: 3/12/2024
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Updated: 9/1/2022
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Inventor(s): George Sutphin, Samuel Freitas, Megha Padi, Chen Chen
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Simulators and Modeling Tools
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