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An Efficient And Improved Chemical Conversion Of The Natural Product Physachenolide D (LG-01) To Its Analogue LG-134 With Potent Anticancer Activity
Invention: An improved process of chemical conversion of the natural plant product physachenolide D (PCD) to a C-18 analogue (LG-134) of physachenolide C (PCC).Background: The standard yield of LG-134 using current methods is relatively low at 1/3 resultant from original products. This method allows for the yield to be double current chemical processes....
Published: 2/27/2023
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Inventor(s): Leslie Gunatilaka, Kithsiri Wijeratne, Yaming Xu
Keywords(s):
Category(s): Technology Classifications > Agriculture & Horticulture, Technology Classifications > Life Sciences > Therapeutics
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An Alternative Mode of RNA Interference Triggered through Feeding Synthetic RNAs that are Processed into piRNAs
This invention describes a new method of the widely-used RNA interference technique with potential clinical and research applications.
Background:
RNA interference is a commonly used method to knockdown or “silence” genes. This is typically done using small interfering RNA (siRNA) probes designed with specificity to bind and tag certain...
Published: 2/27/2023
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Inventor(s): Judith Brown, Mosharrof Hossain Mondal, Jorge Rafael Paredes Montero, Alex Flynt
Keywords(s):
Category(s): Technology Classifications > Agriculture & Horticulture, Technology Classifications > Agriculture & Horticulture > Crop Improvement, Technology Classifications > Life Sciences > RNAi/siRNA, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Therapeutics
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Specific 17-Beta-Hydroxywithanolides Sensitize Cancer Cells to Apoptosis in Response to Toll-like Receptor (TLR)
This invention describes the use of withanolide E for cancer treatment through cancer cell apoptosis (cell self-destruction) through extrinsic pathways of “death ligand” proteins. Withanolide E is a natural product in which the 17-beta-hydroxy group and orientation of the molecule chain result in improved apoptosis sensitivity, with demonstrated...
Published: 7/15/2022
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Inventor(s): Leslie Gunatilaka, Yaming Xu, Kithsiri Wijeratne, Thomas Sayers, Poonam Tewary, Alan Brooks, Curtis Henrich, James McMahon
Keywords(s):
Category(s): Technology Classifications > Agriculture & Horticulture, Technology Classifications > Healthcare Portfolios > Oncology
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Controlled Transfer of Endohyphal Symbionts among Fungal Strains
University of Arizona researchers discovered that diverse endophytic fungi were found to harbor endohyphal bacteria (EHB), which live within apparently healthy, viable fungal cells. Differences in suites of EHB between closely related fungal endophytes suggest horizontal transfer of these symbionts in nature. This relationship appears facultative for...
Published: 7/15/2022
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Inventor(s): Anne Arnold, Kayla Arendt, David Baltrus
Keywords(s):
Category(s): Technology Classifications > Agriculture & Horticulture, Technology Classifications > Agriculture & Horticulture > Crop Improvement
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Semi-Synthetic 17beta-Hydroxywithanolides (17-Bhws) Promote Caspase-8-Dependent Apoptosis in Renal Carcinoma and Melanoma and Specifically Inhibit Human Prostate Cancer Cell Proliferation
This novel, partially naturally-derived compound can be used to treat three different kinds of cancer (melanoma, renal carcinoma, and prostate cancer) in patients without other treatment options.
Background:
The treatment of all kinds of cancers leaves much to be desired in terms of an efficient treatment that is highly effective and has comparably...
Published: 7/15/2022
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Inventor(s): Leslie Gunatilaka, Kithsiri Wijeratne, Yaming Xu, Thomas Sayers, Poonam Tewary, Alan Brooks
Keywords(s):
Category(s): Technology Classifications > Agriculture & Horticulture, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Oncology
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Natural Plant-Based Hand Sanitizer
This invention is a combination of plant-derived extracts formulated to mitigate bacterial and viral pathogens. This combination can be used as a natural hand sanitizer.
Background:
Microorganisms like bacteria and viruses are found on every surfaces. Hand sanitizer is a quick and convenient way to kill the bacteria and viruses encountered in day-to-day...
Published: 7/15/2022
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Inventor(s): Sadhana Ravishankar, Bibiana Law
Keywords(s):
Category(s): Technology Classifications > Agriculture & Horticulture, Technology Classifications > Healthcare Portfolios > Infectious Diseases
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Method, Software and Hardware for Measuring Feeding Nectar Feeders
This device and software is able to detect when an animal drinks the feeding solution of an artificial feeder. The time and duration of independent events at multiple feeding posts can be recorded. Paired software can enable real-time compatibility with the system: feeding behavior can be visualized in real time and commands can be sent remotely to...
Published: 7/15/2022
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Inventor(s): Patrick Heidorn
Keywords(s):
Category(s): Technology Classifications > Agriculture & Horticulture, Technology Classifications > Sensors & Controls, Technology Classifications > Software & Information Technology
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Nematicidal and Antimicrobial Activities of Secondary Metabolites from Photorhabdus Bacteria with Applications in Agriculture
This invention is novel compounds derived from Photorhabdus bacteria that have antimicrobial and nematicidal properties with an application for agriculture.
Background:
Agricultural pests result in severe economic losses around the globe. However, intensive use of chemical pesticides has a cost on the environment. There is currently a trend towards...
Published: 7/15/2022
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Inventor(s): Patricia Stock, Istvan Molnar
Keywords(s):
Category(s): Technology Classifications > Agriculture & Horticulture, Technology Classifications > Agriculture & Horticulture > Crop Improvement
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Methods of Using Viral Replicase Polynucleotides and Polypeptides
Methods of Using Viral Replicase Polynucleotides and Polypeptides
Applications:
Methods for increasing plant cell transformation frequencies, increasing crop yield, providing positive growth advantage, modulating cell division, and providing means of positive selection
Advantages:
Technology increases transformation efficiency over earlier...
Published: 7/15/2022
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Inventor(s): Brian Larkins, Ronald Burnett, Young-Min Woo, Brian Dilkes
Keywords(s):
Category(s): Technology Classifications > Agriculture & Horticulture, Technology Classifications > Life Sciences, Technology Classifications > Agriculture & Horticulture > Crop Improvement, Technology Classifications > Life Sciences > Therapeutics
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Cell Cycle Nucleic Acids, Polypeptides and Uses Thereof - Wee1
This invention improves transformation frequency by changing levels of protein expression in the target cells, altering the cell cycle, specifically by modulating the activity of a gene known as RB3 which influences the cell's progression from G1 to S phase in the cell cycle. Overexpression of RB3 can be induced through existing methods of transient...
Published: 7/15/2022
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Inventor(s): Paolo Sabelli, Yan Liu, Chunsheng Zhang, William Gordon-Kamm, Keith Lowe, Matthew Bailey, Xun Wang, Carolyn Gregory, George Hoerster, John Mcelver, Shane Abbitt, Benjamin Bowen, Brian Larkins, Brian Dilkes, Ricardo Dante, Yeujin Sun
Keywords(s):
Category(s): Technology Classifications > Agriculture & Horticulture, Technology Classifications > Life Sciences, Technology Classifications > Agriculture & Horticulture > Crop Improvement, Technology Classifications > Life Sciences > Therapeutics
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