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Leukocyte Gene Expression Predicts Human Temporal Lobe Epilepsy Seizure Frequency
The leukocyte gene biomarkers presented here identify totally new and different genes whose expression predict temporal lobe epilepsy (TLE) seizure frequency. This seizure frequency prediction is a manifestation of the underlying pathophysiology of TLE disease states which have, heretofore, not been identified to have a dichotomized genetic basis. Targeting...
Published: 9/7/2023
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Inventor(s): Martin Weinand
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Life Sciences > Biomarkers
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TROVE: A Translational Resource for Omics-Based Validation of Expression Datasets
Translational Resource for Omics-Based Validation of Expression (TROVE) is a solution-oriented query-able disease database that integrates various -omic data from animals and humans, reflective of the One Health paradigm. The innovation is focused on dataset integration and identification, to immediately provide targeted solutions for identified infection/immunity...
Published: 7/24/2023
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Inventor(s): Gayatri Vedantam, Virinchipuram Viswanathan, Bryan Roxas
Keywords(s):
Category(s): Technology Classifications > Software & Information Technology > Bioinformatics, Technology Classifications > Software & Information Technology > Health IT, Technology Classifications > Software & Information Technology, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Vaccines
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Method and System for Passive and Active Agent Delivery for Biomarker and Treatment Means
Plant-based extracellular vesicles have features leading to low immunogenicity with innate bioactive agents for targeting and/or treating specific biological effects. They can also be used as carriers with cargo drug from natural or synthetic products with higher bioavailability. The variety of plant categories also provide broad resources for lower...
Published: 11/16/2023
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Inventor(s): Frederic Zenhausern, Jerome Lacombe, Ashlee Harris, Zhu Zhao
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Life Sciences > Drug Delivery
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Diagnostic for Non-Invasive Screening and Early Detection of Adenomyosis
This technology is a non-invasive diagnostic for the screening and detection of adenomyosis. This could be used for women that are suffering with symptoms of chronic pelvic pain and adenomyosis for diagnosis without an invasive hysterectomy. In preliminary studies, there has been high acceptance of a particular sampling, that can provide information...
Published: 11/16/2023
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Inventor(s): Melissa Herbst-Kralovetz, Pawel Laniewski
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Healthcare Portfolios > Women's Health
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Diagnostic for Screening and/or Predicting Women "at risk" for the Development and Progression Endometrial Cancer
This invention describes a novel method to use metabolic markers in samples obtained from cervicovaginal lavage (CVL) and machine-learning algorithms to detect patients “at risk” for endometrial cancer (EMC).
Background:
Endometrial cancer (EMC) is the most common gynecological cancer. The American Cancer Society estimates that in 2021...
Published: 11/16/2023
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Inventor(s): Melissa Herbst-Kralovetz, Pawel Laniewski
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Healthcare Portfolios > Women's Health
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Novel Multi-Omics Aging Clock
A multi-omics clock analyzes multiple layers of omics data with machine learning to predict remaining lifespan of mammals, particularly for animal model studies. Large omics data sets may be used from combinations of genomics, proteomics, lipids, etc. available from blood or other simple sample collection. This tool can robustly capture changes...
Published: 4/3/2023
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Inventor(s): George Sutphin, Samuel Freitas, Megha Padi, Chen Chen
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Simulators and Modeling Tools
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Blood Biomarker for the Diagnosis and Treatment of Chronic Inflammation in the Brain in the Days and Weeks after Stroke
This invention comprises a method of identifying chronic inflammation in the day(s), weeks, or months after a stroke by measuring matrix metalloproteinase-12 (MMP-12) in a patient to determine whether therapeutic intervention is required to help immune cells process lipid debris after stroke to reduce secondary neurodegeneration. MMP-12 is a protein...
Published: 4/3/2023
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Inventor(s): Kristian Doyle
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Research Tools > Protein
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Biomarker for Patient Stratification for Treatment of Cognitive Impairment in Patients with Vascular Contributions to Cognitive Impairment
This technology has found a serum biomarker that is efficacious in stratifying patients with vascular contributions to cognitive impairment and dementia (VCID) and Alzheimer’s disease related dementias (ADRD). This biomarker was able to indicate patients with high levels of VCID that are well suited for treatment with angiotensin peptides.
Background:
Worldwide,...
Published: 11/16/2023
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Inventor(s): Meredith Hay, John Konhilas, Christina Hoyer-Kimura, Thomas Beach, Geidy Serrano, Eric Reiman
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Life Sciences > Diagnostics
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Diagnostic for Monitoring Response to Immunotherapies for Gynecologic Cancer
This invention is a collection of immunological checkpoint proteins and physiological markers to diagnose and potentially monitor treatments for cervical cancer. This biomarker panel would be taken using the cervicovaginal lavage method which is a less invasive than other sampling method for cervical cancer. This diagnostic test could be used not only...
Published: 11/16/2023
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Inventor(s): Melissa Herbst-Kralovetz, Pawel Laniewski
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Women's Health, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Life Sciences > Diagnostics
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Members of the WNT Signaling Pathway as Predictive Markers and Therapeutic Targets in Glioblastoma Multiforme
This technology is a set of biomarkers to predict radiotherapy and chemotherapy outcomes in individual Glioblastoma Multiforme patients to better assess their prognosis and therapy.
Background:
Glioblastoma Multiforme (GBM) is the most aggressive form of brain cancer and is currently treated through surgical intervention, chemotherapy and radiotherapy....
Published: 4/3/2023
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Inventor(s): Eric Weterings, Baldassarre Stea, Daruka Mahadevan, Christopher Morrison, Michael Hammer
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Biomarkers
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