Search Results - victor+hruby

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MC4R Selective Ligand for Obesity and Alzheimer’s Disease Prevention
This technology is a novel peptide that has been shown to be a potent MC4R selective antagonist. It is a potential therapeutic for cognitive loss and obesity. Background: The challenges of neurodegradation, Alzheimer’s disease, and obesity have been shown to have some similar molecular signatures that contribute to disease and have thus created...
Published: 9/26/2022   |   Inventor(s): Minying Cai, Victor Hruby
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Healthcare Portfolios > Diabetes, Metabolism, Endocrinology & Obesity, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules
Selective Melanotropin 4 Ligands for Neurodegenerative Diseases
This technology is the development of ligands that selectively bind to the Melanocortin 3 Receptor (MC3R) and Melanocortin 4 Receptor (MC4R) and modulate receptor activity for neurodegenerative diseases. The melanocortin receptor ligand is bound to an MC3R and/or MC4R selective moiety, which allows the complex to cross the blood brain barrier. The ligand-moiety...
Published: 7/15/2022   |   Inventor(s): Minying Cai, Victor Hruby
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
Enhanced Melanoma Cancer Prevention by Novel Melanotropins
This invention describes a method to stimulate natural production of melanin in the body. This stimulation is provided by a selective gamma-melanocyte stimulating hormone derivative, which incites the increase in melanin in the body. A natural increase confers photo protective properties without the need for UV activation, making it a safe compound. Background: Existing...
Published: 7/15/2022   |   Inventor(s): Minying Cai, Victor Hruby
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Biologics
Topical Delivery of Natural Tanning Active Ingredient for Melanoma Prevention Using Peptides Selective for Melanocortin Receptor 1
This invention is the topical delivery of a natural peptide ingredient to aid in the production of melanin without exposure to UV radiation. The product is stable and selective for the human melanocortin-1 receptor (hMC1R), avoiding off-target effects with non-selective melanocortin ligands. Background: Melanoma is the most dangerous form of skin...
Published: 7/15/2022   |   Inventor(s): Minying Cai, Victor Hruby
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Dermatology
Selective Melanotropin Ligands for Neurodegenerative Diseases including Parkinson's
This technology involves administering an α-melanocyte-stimulating hormone through a carrier to selective melanotropin receptor ligands to treat neurodegenerative diseases. Specifically, this technology allows melanotropin to be administered through either one or both, the melanocortin 3 receptor (MC3R) and melanocortin 4 receptor (MC4R). Background: There...
Published: 7/18/2022   |   Inventor(s): Minying Cai, Victor Hruby
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Drug Delivery
Modulators of Melanocortin Receptors for the Treatment of Depression and Anxiety
This invention is the use of the melanocortin 5 receptor (MC5R) ligand to treat depressive and anxiety disorders. MC5R antagonism is the proposed mechanism of action. Background: Depression and anxiety often have similar treatment, but experiencing the full effects of current pharmacotherapy can range from weeks to months. Antidepressants and anxiolytics...
Published: 1/13/2023   |   Inventor(s): Victor Hruby, Minying Cai
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Neurology > Mental Health, Technology Classifications > Life Sciences > Therapeutics
Method for the Treatment of Depression and Anxiety
This technology relates to a modified version of SHU9119, a peptide chain that is known to interact with Melanocortin. This modified version of SHU9119 can antagonize the Melanocortin 5 Receptor (MC5R), potentially enabling rapidly-acting drugs to target these receptors and provide therapeutic relief for those suffering from depression and other mood...
Published: 7/15/2022   |   Inventor(s): Victor Hruby, Minying Cai, Horst Kessler
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Therapeutics
Methods for the Treatment of Central Nervous System (CNS) Disorders and Mood Disorders
This technology is a modified version of SHU9119, a peptide chain that is known to interact with Melanocortin Receptors. This modified version of SHU9119 can antagonize a Melanocortin 5 Receptor, allowing rapidly acting drugs to target these receptors and provide therapeutic relief for those suffering from depression and other mood disorders. Background: Current...
Published: 7/15/2022   |   Inventor(s): Victor Hruby, Minying Cai
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Therapeutics
Novel Modulators of Melanocortin Receptors for the Treatment of Depression and Anxiety
This technology describes a cyclic peptide modification that allows for antagonistic binding toward melanocortin 5 receptor (MC5R). Evidence links this receptor to depression and mood disorders, allowing the invention to effectively treat certain mental disorders. Background: SHU9119 is a peptide chain that is known to interact with melanocortin...
Published: 7/15/2022   |   Inventor(s): Victor Hruby, Minying Cai
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Therapeutics
Method for the Treatment of Depression
This invention involves utilizing a composition, PG-20N, to treat depression or anxiety. It is specifically designed to treat conditions with a selective melanocortin 5 (MC5R) antagonist. Melanocortins exert many biological activities in the brain including control of feeding, grooming, hyperalgesia, social and sexual behaviors, central regulation of...
Published: 7/15/2022   |   Inventor(s): Victor Hruby, Minying Cai, Caurnel Morgan
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Small Molecules
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