A Peptide Approach to Block eNOS Phosphorylation at T495

Case ID:

This invention is a peptide that blocks eNOS phosphorylation. These peptides are designed to target to block T495 phosporylation site of eNOS. When done, this would prevent the activation of eNOS that leads to superoxide production and overwhelming inflammation. The initial peptide has been shown to reduce NOS derived superoxide and cell barrier loss throughout trials.



Pulmonary hypertension and ventilation-induced acute lung injury can be devastating conditions for any person that has them. Pulmonary hypertension is a type of high blood pressure that affects the arteries in the lungs and the right side of the heart. These lung diseases cause obvious breathing problems and affect the quality of life of any person who has them. For obvious reasons, there has been a great deal of medical attention, research, and monetary support to address the problems that these diseases cause in the lives of the patients who have them. Protein nitration has been shown to be an important driver for these inflammatory disease.



  • Blocking eNOS phosphorylation
  • Preventing the damage caused by diseases, including:
    • Pulmonary hypertension
    • Ventilation-induced acute lung injury



  • Help to prevent the onset of certain diseases, including their dangerous symptoms
Patent Information:
Contact For More Information:
Mitch Graffeo
Sr. Licensing Manager - COM-T
The University of Arizona
Lead Inventor(s):
Stephen Black
Evgeny Zemskov
Qing Lu