Methods for Practical Synthesis of Deuterated Aldehydes

Case ID:

This technology is an organocatalytic strategy that enables directly converting readily accessible aldehydes to their 1-deutero counterparts. The approach is distinct from the reported transition metal catalyzed ionic hydrogen-deuterium exchange (HDE) processes. The power of this new process has not only been demonstrated for aromatic aldehydes, but also for aliphatic substrates, which have been difficult for HDE, and for selective late-stage deuterium incorporation into complex structures with uniformly high deuteration level (>90%)


Among isotopes, deuterium perhaps has the broadest impact on almost every sub-discipline in the life, and chemical, material and nuclear sciences and beyond. The recent surge in applications of deuterated pharmaceutical agents has been witnessed by the FDA approval of the first deuterated drug, austedo (deutetrabenazine), in 2017 and the large number of emerging deuterated drug candidates. This has created an urgent demand for synthetic methods that enable the efficient generation of deuterated building blocks.


  • Synthesis of deuterated aldehydes



  • Efficient
  • Minimal steps
  • Ability to produce a wide range of compounds
Patent Information:
Contact For More Information:
Katherine Kuhns
Licensing Manager, UAHS-TLA
The University of Arizona
Lead Inventor(s):
Wei Wang