The UniDec Processing Pipeline (UPP)

Case ID:
UA23-217
Invention:

This mass spectrometry analysis software and method extends the UniDec Bayesian deconvolution algorithm for application to rapid analysis of biotherapeutics, including determining the drug-to-antibody ratio for antibody-drug conjugates and calculating the correct pairing of bispecific antibodies.  

Background:
Mass spectrometry (MS) and intact mass analysis are increasingly common in academic and industry research.  This has created a demand for more robust approaches to MS analysis. UniDec is one approach. UniDec is a software package based on a Bayesian deconvolution algorithm. The algorithm provides a rapid and robust approach to deconvolving electrospray mass spectra into their corresponding mass and charge components.  

Applications:

  • Mass spectrometry analysis
  • Biomolecules
  • Antibody-drug conjugates

Advantages:

  • Streamlines analysis for antibody-drug conjugates
  • Improves data quality
  • Removes deconvolution artifacts
Patent Information:
Contact For More Information:
Laura Silva
Sr. Licensing Manager, COS
The University of Arizona
lauras@tla.arizona.edu
Lead Inventor(s):
Michael Marty
Keywords: