Search Results - aubin+moutal

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Treatment of Craniofacial Pain Disorders
This invention uses the gene-editing technique CRISPR/Cas9 to target pain-related proteins in the trigeminal ganglion. This editing was shown to inhibit migraine-like pain in female mice and has potential to treat craniofacial pain disorders and has long-lasting analgesic effects. Background: Many people suffer from craniofacial pain disorders, with...
Published: 7/15/2022   |   Inventor(s): Frank Porreca, Edita Navratilova, Aubin Moutal, Rajesh Khanna
Category(s): Technology Classifications > Healthcare Portfolios
Zinc Finger Protein Transcription Factors for Repression of Pain Genes
This invention proposes the use of zinc finger protein transcription factors (ZFP-TFs) technology to repress the expression of specific genes associated with chronic pain. The Zinc finger technology allows for the inhibition of gene expression with high affinity and specificity, and is purposed here to be used against Vascular endothelial growth factor-A...
Published: 7/15/2022   |   Inventor(s): Rajesh Khanna, Aubin Moutal, Casey Case, Manal Mehta
Category(s): Technology Classifications > Life Sciences
Blocking NRP-1 for the Treatment of Pain, Cancer and Prevention of Viral Entry
This invention discloses a novel method for the treatment of pain and cancer as well as the prevention of viral entry, most notably SARS-CoV-2. The inventors have identified a number of promising lead compounds which bind to and interrupt neuropilin 1 (NRP-1) signaling. This is an important first step in the development of small molecule inhibitors...
Published: 8/19/2022   |   Inventor(s): Rajesh Khanna, Aubin Moutal, Samantha Perez-Miller
Category(s): Technology Classifications > Life Sciences > Small Molecules