Search Results - rajesh+khanna

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A Novel Pan-T-Type Calcium Channel Modulator that alleviates Tonic, Neuropathic and Inflammatory Pain
This invention describes a non-opioid method to treat pain using a novel T-type calcium channel blocker. Background: Current treatments for many types of pain typically include opioid painkillers, which pose a significant risk of addiction and overdose in patients, creating a demand for a treatment with less risk and less side-effects. In neuropathic,...
Published: 2/10/2022   |   Inventor(s): Rajesh Khanna, Jun Wang
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Category(s): Technology Classifications, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Small Molecules
Treatment of Craniofacial Pain Disorders
This invention uses the gene-editing technique CRISPR/Cas9 to target pain-related proteins in the trigeminal ganglion. This editing was shown to inhibit migraine-like pain in female mice and has potential to treat craniofacial pain disorders and has long-lasting analgesic effects. Background: Many people suffer from craniofacial pain disorders, with...
Published: 8/4/2021   |   Inventor(s): Frank Porreca, Edita Navratilova, Aubin Moutal, Rajesh Khanna
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Category(s): Technology Classifications > Healthcare Portfolios
Zinc Finger Protein Transcription Factors for Repression of Pain Genes
This invention proposes the use of zinc finger protein transcription factors (ZFP-TFs) technology to repress the expression of specific genes associated with chronic pain. The Zinc finger technology allows for the inhibition of gene expression with high affinity and specificity, and is purposed here to be used against Vascular endothelial growth factor-A...
Published: 2/2/2021   |   Inventor(s): Rajesh Khanna, Aubin Moutal, Casey Case, Manal Mehta
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Category(s): Technology Classifications > Life Sciences
Blocking NRP-1 for the Treatment of Pain, Cancer and Prevention of Viral Entry
This invention discloses a novel method for the treatment of pain and cancer as well as the prevention of viral entry, most notably SARS-CoV-2. The inventors have identified a number of promising lead compounds which bind to and interrupt neuropilin 1 (NRP-1) signaling. This is an important first step in the development of small molecule inhibitors...
Published: 10/6/2020   |   Inventor(s): Rajesh Khanna, Aubin Moutal, Samantha Perez-Miller
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Category(s): Technology Classifications > Life Sciences > Small Molecules
T-Type Calcium Channel Enhancer for TAF1 Associated Neurological Defects
This invention relates to TAF1-ID animal model and new use for SAK3 which was first developed as a T-type voltage gated Ca2+ channel enhancer for treating TAF1 intellectually disability (TAF1 ID) syndrome, an x-linked disorder caused by loss-of-function mutations in the TAF1 gene. Background: TATA-box binding protein associated factor 1 (TAF1) plays...
Published: 6/15/2020   |   Inventor(s): Mark Nelson, Rajesh Khanna, Janakiraman Udaiyappan, Dhanalakshmi Shankara Raman
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Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Therapeutics
Discovery of T-Type Calcium Channel Antagonist from Multicomponent Reactions and their Application in Paclitaxel-Induced Peripheral Neuropathy
This invention uses innovative selective T-type antagonists in order to ease pain involved with chemotherapy-induced peripheral neuropathy (CIPN). Background: Chemotherapy remains a frontline treatment for many forms of cancer, however, chemotherapy agents commonly cause severe side effects such as CIPN. While opioids have been used to manage CIPN,...
Published: 5/15/2020   |   Inventor(s): Jun Wang, Rajesh Khanna
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Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics