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Design and Synthesis of a New Class of G-Quadruplex Binding Ligands for the Treatment of Cancer
This technology identifies new chemical entities (NCEs) that, according to FRET assay, target the G-quadruplex secondary DNA structure. The disclosed NCEs possess structural features with side chains that may improve potency with specificity over previously reported c-Myc suppressors. The Hurley lab previously discovered that stabilization of a specific...
Published: 11/16/2023   |   Inventor(s): Laurence Hurley, Biswanath De, Venkateshwar Chappeta, Tracy Brooks, Vijay Gokhale, Cristina Beman, Heather Perry
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics