Search Results - laurence+hurley

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2-Aryl-Pyridylazoles for the Treatment of Solid Tumors such as Pancreatic Cancer
University of Arizona researchers have identified two potent small molecules that target a common mutation found in pancreatic cancer cells with high specificity and induce cell death. These compounds are genotype specific for the DPC4 mutation associated with cancer phenotypes and, compared to available treatments, are significantly more potent and...
Published: 8/29/2022   |   Inventor(s): Robert Dorr, Gary Flynn, Haiyong Han, Meredith Henderson, Laurence Hurley, Yeng Jeng Shaw, Daniel Von Hoff
Keywords(s):  
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Small Molecules
G-Quadruplex Targeting Small Molecules for the Treatment of Castration Resistant Prostate Cancer and HSV-1
This technology consists of a new class of small-molecules that target G-quadruplex formation. These compounds have the potential to treat a wide variety of diseases including prostate cancer. In particular, these compounds are aimed at helping individuals who have developed a resistance to androgen-deprivation therapies (ADT). While most ADT therapeutics...
Published: 7/15/2022   |   Inventor(s): Elsa Reyes Reyes, Cynthia Miranti, Laurence Hurley, Vijay Gokhale, Kui Wu, Sara Richter
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics
Design and Synthesis of a New Class of G-Quadruplex-Binding Ligands for the Treatment of Cancer and Other Diseases
c-Myc is an essential transcription factor that plays an important role in cell proliferation, differentiation, as well as maintenance of other cell-cycle functions. Under pathologic conditions, c-Myc expression is highly elevated, contributing to development of malignancy in majority of human cancers. Thus researchers have been looking for compounds...
Published: 7/15/2022   |   Inventor(s): Laurence Hurley, Vijay Gokhale, Srinivasa Reddy Kota, Seongmin Hahn
Keywords(s): anticancer activity, G-quadruplex, quindolines
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics
Design and Synthesis of a New Class of G-Quadruplex Binding Ligands for the Treatment of Cancer
This technology identifies new chemical entities (NCEs) that, according to FRET assay, target the G-quadruplex secondary DNA structure. The disclosed NCEs possess structural features with side chains that may improve potency with specificity over previously reported c-Myc suppressors. The Hurley lab previously discovered that stabilization of a specific...
Published: 7/15/2022   |   Inventor(s): Laurence Hurley, Biswanath De, Venkateshwar Chappeta, Tracy Brooks, Vijay Gokhale, Cristina Beman, Heather Perry
Keywords(s):  
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics
Combination Treatment for Cancer Involving CX-3543 and a PARP Inhibitor
Researchers at the University of Arizona have discovered that the addition of benzamide to HeLA cells prior to treatment with CX-3543 results in an increase in nucleolin bound to the NHE III1 element of the c-Myc promoter. Further analysis of the data indicated that there is a significant increase in the induction of apoptosis over that of CX-3543 alone....
Published: 7/15/2022   |   Inventor(s): Laurence Hurley, Daekyu Sun, Mary Guzman, Tiffanie Powell Bialis, Veronica Gonzalez-Pena
Keywords(s):  
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Small Molecules