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Polymeric Heart Valve System and Method of Manufacture
This invention is a new polymer-based heart valve designed to reduce stress on the leaflets of the valve while in use in the human body, providing for longer-term durability compared to other polymer-based valves.
Background:
According to the CDC, heart disease is the leading cause of death in the United States: about one in every four deaths is due...
Published: 8/31/2022
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Inventor(s): Marvin Slepian, Danny Bluestein, Oren Rotman, Brandon Kovarovic
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Materials > Medical Device Material
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Biomarker Signatures of Platelet Activation
This invention is a mechanical biomarker signature of shear effects on cells for the purpose of detecting thrombosis early so it can be treated or intercepted prior to a thrombotic event.
Background:
Thrombosis is a pathophysiological event that can trigger conditions like stroke or heart attack. The efficacy of many antithrombotic agents is shear...
Published: 7/15/2022
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Inventor(s): Marvin Slepian, Yana Roka-Moiia, Danny Bluestein, Naing Bajaj, Michael Dicaro, Louise Hecker
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Healthcare Portfolios > Oncology
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HyperShear in a Channel: A Microfluidic Facsimile of Ventricular Assist Devices to Reduce Thrombotic Risk and Enhance Patient Safety
This technology utilizes device thrombogenicity emulation--a method which mimics the shear stresses that would be exhibited within the patient in order to assess proper anti-thrombolytic therapies. Shear stresses are observed in a microfluidic facsimile of a ventricular assist device (VAD), which can quickly be translated to assess the personal risk...
Published: 8/29/2022
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Inventor(s): Marvin Slepian, Alberto Redaelli, Danny Bluestein, Marco Rasponi
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Materials > Medical Devices > Diagnostic
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