Search Results - daruka+mahadevan

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Novel mRNA-based Prognostic Index Derived from Differential Expression Analysis Improves Overall Survival Estimates in Glioblastoma
This technology is a set of biomarkers to predict radiotherapy and chemotherapy outcomes in individual Glioblastoma Multiforme patients to better assess their prognosis and therapy. Background: Glioblastoma Multiforme (GBM) is the most aggressive form of brain cancer and is currently treated through surgical intervention, chemotherapy and radiotherapy....
Published: 4/19/2022   |   Inventor(s): Eric Weterings, Baldassarre Stea, Daruka Mahadevan, Michael Hammer, Christopher Morrison
Keywords(s):  
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Healthcare Portfolios
Amuvatinib-Dependent Degradation of Rad51 is Proteasome-Mediated
This technology is a combination of cisplatin with amuvatinib (MP-470) for the treatment of cisplatin-resistant pancreatic cancer cells. Cisplatin is a chemotherapy medication used to treat several cancers and amuvatinib is an oral drug that has been used in trials for treating solid tumors and small cell lung carcinoma. The invention is directed to...
Published: 10/6/2020   |   Inventor(s): Daruka Mahadevan, Nathan Ellis
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Category(s): Technology Classifications > Life Sciences > Biologics
Breast Tumor Targeted Fluorescence Guidance for Intraoperative Margin Assessment
This technology is an anti-CEACAM6 antibody tagged with fluorescent labels. The idea is that these fluorescent antibodies can be used for real-time molecular fluorescence imaging to help guide the surgical removal of a tumor. This technology is targeted toward breast cancer. Background: Over half of the 270,000 breast cancer diagnoses in the United...
Published: 5/7/2020   |   Inventor(s): Daruka Mahadevan, David Morse
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Category(s): Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Healthcare Portfolios > Oncology
Inhibitors of the DNA - KU70/80 Association to Sensitize Cells for Radiation or Chemotherapy
This invention provides methods and compositions for inhibiting cancer cell survival and/or promoting cell death following radiation or chemotherapy applied in cancer treatment. This invention is a second set of Ku70/80 inhibitors that can sensitize cancer cells for chemotherapy. A first set of Ku70/ 80 inhibitors was previously discovered by University...
Published: 3/6/2019   |   Inventor(s): Eric Weterings, Daruka Mahadevan, Josef Vagner
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics
Members of the WNT Signaling Pathway as Predictive Markers and Therapeutic Targets in Glioblastoma Multiforme
This technology is a set of biomarkers to predict radiotherapy and chemotherapy outcomes in individual Glioblastoma Multiforme patients to better assess their prognosis and therapy. Background: Glioblastoma Multiforme (GBM) is the most aggressive form of brain cancer and is currently treated through surgical intervention, chemotherapy and radiotherapy....
Published: 1/9/2019   |   Inventor(s): Eric Weterings, Baldassarre Stea, Daruka Mahadevan, Christopher Morrison, Michael Hammer
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Biomarkers
Small Molecular Weight Inhibitors of the DNA - KU70/80 Association to Sensitize Cells for Radiation or Chemotherapy
This invention provides methods and compositions for inhibiting cancer cell survival and/or promoting cell death following radiation or chemotherapy applied in cancer treatment. This invention can be used to treat cancer alone as well. University of Arizona investigators found compounds that may disrupt the Ku70/80 – DNA repair association. The...
Published: 9/11/2015   |   Inventor(s): Eric Weterings, Daruka Mahadevan, Josef Vagner
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Oncology