Search Results - edon+vitaku

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Novel Small Molecule Compounds with Neuroprotective Potential in ALS and Related Neurodegenerative Diseases
This invention comprises a series of novel small molecule compounds developed at the University of Arizona and their method of use for the treatment of locomotor dysfunction associated with Amyotrophic Lateral Sclerosis (ALS) and other diseases associated with proteinopathy of a transactive response (TAR) DNA binding protein, TDP-43. Testing in a previously...
Published: 9/2/2021   |   Inventor(s): Daniela Zarnescu, Jon Njardarson, Isaac Chogii, David Smith, Edon Vitaku, Rachel Allen
Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Therapeutics
Novel Method for Synthesis of Indoles
This invention describes a novel method of generating heterocyclic compounds via a 3+2 annulation. This method does not require expensive reagents and, in some instances, can be completed in a chiral manner. Background: Existing methods to synthesize heterocycles usually require multiple steps, metal catalysts, and/or relatively expensive reagents....
Published: 10/30/2015   |   Inventor(s): Jon Njardarson, Edon Vitaku
Category(s): Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Materials > Ceramics, Technology Classifications > Materials > Biocompatible, Technology Classifications > Materials > Medical Devices > Therapeutic, Technology Classifications > Research Tools > Protein, Technology Classifications > Research Tools > Reagents
Meta-Selective Alkylation of Phenolic Substrates
The technology is a method of meta-selective alkylation which requires no heating and has short reaction times relative to existing processes. The process relies on dearomatization of phenolic rings, introduction of the functional group at the meta- position, and rearomatization of the phenol. The process requires no directing group. Background:...
Published: 4/28/2015   |   Inventor(s): Jon Njardarson, Edon Vitaku
Category(s): Technology Classifications > Materials > Chemicals, Technology Classifications > Materials > Processing
Metal Free Scalable Synthesis of Fluorinated Indole and Benzofuran Structures
This technology is a novel one step method to generate fluorinated aryl groups for use in various other reactions. Background: There are few alternative existing methods to treat arrhythmia. Originally, there were a slew of powerful anti arrhythmic drugs on the market which had the potential to treat the cardiovascular condition. However, the majority...
Published: 10/6/2014   |   Inventor(s): Jon Njardarson, Edon Vitaku, David Smith
Category(s): Technology Classifications > Materials > Processing