Novel Method for Synthesis of Indoles

Case ID:

This invention describes a novel method of generating heterocyclic compounds via a 3+2 annulation. This method does not require expensive reagents and, in some instances, can be completed in a chiral manner.


Existing methods to synthesize heterocycles usually require multiple steps, metal catalysts, and/or relatively expensive reagents. This invention possesses no such drawbacks and creates heterocycles in a one pot reaction. These heterocyclic compounds can be used to then synthesize a variety of therapeutically relevant compounds.



  • Anti-HIV compounds
  • Anti-hypertensive compounds
  • Analgesics
  • Cancer therapeutics



  • Cost effective relative to the existing options
  • One pot reaction allows for faster turnaround 
  • Generation of chiral compounds
Patent Information:
Contact For More Information:
Laura Silva
Sr. Licensing Manager, COS
The University of Arizona
Lead Inventor(s):
Jon Njardarson
Edon Vitaku