Search Results - robin+polt

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Amphipathic Helical Glycopeptide Address Sequences for Enhanced Blood-Brain Barrier Transport of Neuroactive Peptides
University of Arizona researchers have successfully created a series of amphipathic helical glycopeptides with the ability to retain a membrane bound conformation promoting endocytosis as well as a water-soluble conformation facilitating exit from the membrane. This "biousian" property is intrinsic in allowing the molecule to traverse the...
Published: 7/15/2022   |   Inventor(s): Robin Polt, Dhanasekaran Muthu
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Category(s): Technology Classifications > Life Sciences, Technology Classifications > Engineering & Physical Sciences
Neuroprotection via Glycosylated PACAP Analogues with Differentiated Selectivity toward PAC1 and VPAC1 > VPAC2
Inventors at the University of Arizona have developed glycopeptide analogues of PACAP which exhibit selective PAC1 and/or VPAC1 receptor activity with a reduced VPAC2 receptor activity as compared to native PACAP, an endogenous peptide hormone associated with neuronal tissue repair. Thus, these compounds have positive benefits of PAC1 and VPAC1 activation...
Published: 7/15/2022   |   Inventor(s): Robin Polt, Parthasaradhi Reddy Tanguturi, Christopher Apostol, John Streicher, Lajos Szabo
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Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
Novel Peptides Bioavailable to the Brain for Non-Opioid Pain Relief and/or Addiction Treatment
Inventors at the University of Arizona have developed oxytocin analogues which have high potency, are designed to be more stable compared to the native oxytocin hormone (an endogenous peptide which inhibits pain and promotes social connection), have very high selectivity for oxytocin receptors, and are bioavailable for brain therapeutics. These druggable...
Published: 1/24/2023   |   Inventor(s): Lajos Szabo, Robin Polt, John Streicher, Michael Heien, Parthasaradhi Reddy Tanguturi
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Category(s): Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Healthcare Portfolios > Neurology > Mental Health, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
Glycolipid and Mixed Micelle Characterization via Diffusion-Ordered Spectroscopy
This invention is a spectroscopy method to measure and observe solutions such as aggregates for the purpose of characterizing glycolipid surfactants. Background: Surfactants are known compounds that lower surface tension between two liquids, or a liquid and a solid, with application in detergents, wetting agents, foams, etc. Most industrial surfactants...
Published: 11/22/2022   |   Inventor(s): Dillon Hanrahan, Lajos Szabo, Robin Polt, Michael Heien, Chenxi Liu
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Category(s): Technology Classifications > Materials, Technology Classifications > Research Tools
Carbohydrate-Based Surfactants and Methods of Production
This invention is a method to produce carbohydrate-based surfactants with repeated succession using a glycosylation promotor. Background: Current amphiphilic molecules, surfactants, emulsifiers, cleaning products and food additives are mostly made from synthetic surfactants. Commonly these surfactants are prepared from petroleum-based materials...
Published: 1/23/2023   |   Inventor(s): Jeanne Pemberton, Robin Polt, Raina Maier, Ricardo Palos Pacheco
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Category(s): Technology Classifications > Life Sciences > Nutraceuticals
Glycopeptide and Classical Drug Design
This invention relates to the glycosylation drug candidates to increase penetration, bioavailability, and stability. Background: Transmembrane proteins provide a pathway for drugs to interact with a cell's interior. Drugs commonly target G-protein coupled receptors (GPCRs), comprising 40% of the market. Peptides and small molecule drugs directed...
Published: 7/15/2022   |   Inventor(s): Robin Polt, Christopher Apostol, Michael Heien, Chenxi Liu, John Streicher, Lajos Szabo, Torsten Falk
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Drug Delivery
Pseudoprolines in Neuropeptides
This invention describes the use of pseudo peptides to cross the blood-brain barrier and bind to targeted receptors to achieve pharmaceutical effects. Background: Increased research has led to the exploration of peptides delivering compounds by diffusing across the blood-brain barrier. Many peptide-based drugs are not created using pseudo-peptides,...
Published: 7/15/2022   |   Inventor(s): Robin Polt, Evan Jones
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Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Materials > Chemicals, Technology Classifications > Materials > Biomaterials, Technology Classifications > Research Tools > Protein, Technology Classifications > Materials > Medical Devices > Diagnostic, Technology Classifications > Materials > Medical Devices > Therapeutic
Glycosylation of Secretin Peptides to Improve Drug-Like Properties
This invention is the development of pituitary adenylate cyclase activating peptide (PACAP) agonists for neuroprotection and antagonists for migraine. Background: PACAP is known as a neuronal survival factor, regulating the development, maintenance, function, and plasticity of neurons through activating PAC1, VPAC1, and VPAC2 receptors. Glycosylated...
Published: 7/15/2022   |   Inventor(s): Robin Polt, Evan Jones, Bobbi Anglin, Michael Heien, John Streicher
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences