Pseudoprolines in Neuropeptides

Case ID:
UA16-048
Invention:

This invention describes the use of pseudo peptides to cross the blood-brain barrier and bind to targeted receptors to achieve pharmaceutical effects.

 

Background:
Increased research has led to the exploration of peptides delivering compounds by diffusing across the blood-brain barrier. Many peptide-based drugs are not created using pseudo-peptides, however, glycosylation plays a key role in manipulating the structure of existing peptides. This invention uses glycosylation to create a newly folded peptide that can then be used in a variety of pharmaceutical applications to produce medicinal effects.

 

Applications:

  • Targeted drug delivery
  • Biosensors
  • Diagnostic imaging

 

Advantages:

  • Increased capability to cross the blood-brain barrier
  • Increased affinity to bind to specific targeted receptors
  • Breakdown of the compound may not yield any toxic effects
Patent Information:
Contact For More Information:
Laura Silva
Sr. Licensing Manager, COS
The University of Arizona
lauras@tla.arizona.edu
Lead Inventor(s):
Robin Polt
Evan Jones
Keywords: