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Reversible Crosslinking to Preserve Cell-Specific Gene Expression Across Biospheres
This invention includes chemical methods and reagents to reversibly immobilize the cellular state of gene expression in the field followed by the release of the immobilization in the laboratory for analysis of the gene expression state. Support for this invention was provided by CALS via the Hatch allocation.
Background:
Characterization of single-cell...
Published: 4/3/2023
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Inventor(s): David Galbraith
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Research Tools > Screening assays
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Breast Density Assessment Device
This invention is a non-invasive, inexpensive, comfortable and portable diagnostic test to screen for breast cancer. Designed for early detection particularly among minority populations and as a preliminary screening tool before mammography or MRI assessment. Bioelectrical impedance analysis is a simple, quick, and non-invasive technique for measuring...
Published: 4/3/2023
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Inventor(s): Jennifer Bea
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Medical Devices
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Diagnostic for Non-Invasive Screening and Early Detection of Adenomyosis
This technology is a non-invasive diagnostic for the screening and detection of adenomyosis. This could be used for women that are suffering with symptoms of chronic pelvic pain and adenomyosis for diagnosis without an invasive hysterectomy. In preliminary studies, there has been high acceptance of a particular sampling, that can provide information...
Published: 4/3/2023
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Inventor(s): Melissa Herbst-Kralovetz, Pawel Laniewski
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Healthcare Portfolios > Women's Health
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Neonatal Anorectal Tonometer with Disposable/Detachable Tip
This technology is a neonatal anorectal tonometer that involves a detachable, fluid-filled tip with a quick release system involving (magnet & plate) that connects the tip to a force sensor inside the handle of the device. This device can be used as a substitute for digital rectal exams.
Background:
Cauda Equina Syndrome (CES) occurs when the Cauda...
Published: 4/3/2023
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Inventor(s): Eniko Enikov
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Emergency Medicine, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Sensors & Controls, Technology Classifications > Sensors & Controls > Motion & Force
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Stroke Outcome Prediction using Vascular Imaging Features
This is a prediction method to determine the outcome of a stroke based on vascular images presented by the patient. This model predicts the 90-day functional outcome after ischemic stroke at a significantly higher accuracy than current models, to inform treatment decisions and patient selection. Machine learning models were employed and trained with...
Published: 4/3/2023
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Inventor(s): Kaveh Laksari, Aditi Deshpande, Jordan Elliott, Pouya Tahsili-Fahadan
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Diagnostics
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Method for Diagnosing, Imaging, and Treating Overwhelmed Myelin Lipid Processing within Immune Cells in the Brain After Stroke
It was discovered that foam cells form within primary infarcts and areas of secondary neurodegeneration after stroke. This invention provides for a method of noninvasive imaging and assessment of fatty acid oxidation in the brain after stroke using radionuclide and magnetic resonance-based imaging currently used to measure myocardial fatty acid oxidation...
Published: 4/3/2023
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Inventor(s): Kristian Doyle
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Life Sciences > Diagnostics
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Non-Imaging, Random-Sampling Second Harmonic Generation Measurements to Distinguish Colon Cancer
Second-harmonic generation (SHG) microscopy has emerged as a powerful modality for imaging fibrillar collagen in a diverse range of tissues. A preliminary study demonstrated that non-imaging, randomly sampled SHG intensity measurements are likely sufficient to distinguish normal colorectal tissue from tumor/tumor-adjacent tissue with digital simulation...
Published: 4/3/2023
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Inventor(s): Jenna Montague, Jennifer Barton, Hasina Shir
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Healthcare Portfolios, Technology Classifications > Healthcare Portfolios > Oncology
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Diagnostic for Screening and/or Predicting Women "at risk" for the Development and Progression Endometrial Cancer
This invention describes a novel method to use metabolic markers in samples obtained from cervicovaginal lavage (CVL) and machine-learning algorithms to detect patients “at risk” for endometrial cancer (EMC).
Background:
Endometrial cancer (EMC) is the most common gynecological cancer. The American Cancer Society estimates that in 2021...
Published: 4/3/2023
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Inventor(s): Melissa Herbst-Kralovetz, Pawel Laniewski
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Healthcare Portfolios > Women's Health
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Sensitive, Low-Cost Detection of SARS-CoV-2 from Clinical Saline Gargle Samples Using Smartphone Fluorescence Microscope
This invention is a method of rapidly detecting SARS-CoV-2 in clinical saline samples using a smartphone fluorescence microscope-based immunofluorescence. This method can detect samples of SARS-CoV-2 in saline gargle solutions down to 10 ag/μl (below single copy level). A saline sample is collected, loaded onto a paper-based microfluidic chip, and...
Published: 4/3/2023
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Inventor(s): Jeong-Yeol Yoon
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diagnostics
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An Alternative Mode of RNA Interference Triggered through Feeding Synthetic RNAs that are Processed into piRNAs
This invention describes a new method of the widely-used RNA interference technique with potential clinical and research applications.
Background:
RNA interference is a commonly used method to knockdown or “silence” genes. This is typically done using small interfering RNA (siRNA) probes designed with specificity to bind and tag certain...
Published: 5/22/2023
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Inventor(s): Judith Brown, Mosharrof Hossain Mondal, Jorge Rafael Paredes Montero, Alex Flynt
Keywords(s):
Category(s): Technology Classifications > Agriculture & Horticulture, Technology Classifications > Agriculture & Horticulture > Crop Improvement, Technology Classifications > Life Sciences > RNAi/siRNA, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Therapeutics
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