Search Results - technology+classifications+%3e+life+sciences+%3e+therapeutics

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DYRK/CLK PROTACS
This invention describes a set of novel molecules that target and degrade DYRK/CLK for several potential therapeutic purposes. Background: Proteolysis-targeting chimeric molecules (PROTACs) are small molecules used to decrease a gene’s protein expression by targeting the protein for ubiquitination and degradation after it is created. This mechanism...
Published: 1/17/2023   |   Inventor(s): Christopher Hulme, Kevin Schofield, Walter Becker, Garrit Wilms
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
Treating or Preventing Anorexia Nervosa via Precision Targeting of Neuronal Circuit
­This invention provides methods of treating one or more eating disorders, including anorexia nervosa, bulimia, and related clinical syndromes. A new treatment strategy has been discovered, comprising inhibiting two different neural circuits, which rescues all three of the activity-based anorexia (ABA) animal model phenotypes of extreme increases...
Published: 11/8/2022   |   Inventor(s): Haijiang Cai, Wesley Schnapp
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Healthcare Portfolios > Neurology > Mental Health, Technology Classifications > Life Sciences > Therapeutics
Peptide Therapeutic for Immune Response Activation against Metastatic Triple Negative Breast Cancer
­This invention provides compositions and methods for treating triple negative breast cancer using peptides or peptide mimics that bind to epidermal growth factor receptor (EGFR) to block EGFR nuclear translocation. This mode of action alters EGFR-dependent gene transcription, induces the loss of cancer cell survival and migratory capacity, and...
Published: 1/26/2023   |   Inventor(s): Joyce Schroeder, Angelica Escoto, Benjamin Atwell
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics
Synapse Surgery Tools for Neural Circuit-Specific Synapse Ablation and Modification
Researchers at the University of Arizona have developed novel synapse manipulation tools, so called synapse surgery tools, using the endogenous synapse pruning system. Complement proteins tagging system for target synapses are effective in eliminating specific synapses relevant to neuronal functions and diseases. To accomplish this, the technology is...
Published: 11/21/2022   |   Inventor(s): Deveroux Ferguson, Hee-Dae Kim
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Research Tools
Small Molecule Chaperones of CLN1 and CLN2
The inventors here have identified small molecules that target palmitoyl-protein thioesterase 1 (PPT1), tripeptidyl peptidase 1 (TPP1), enzymes that are deficient and less active in Batten disease or Neuronal Ceroid Lipofuscinosis. The CLN1 and CLN2 genes regulate the production of these enzymes, respectively. Background: Batten Disease, or Neural...
Published: 9/6/2022   |   Inventor(s): May Khanna, Jena Lipsa
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
Tetrazolium-Based Pro-Chelators as New Anticancer Agents
This invention comprises a class of tetrazolium-based prochelators for targeting and binding intracellular iron for selective cancer cell antiproliferation or other iron dysregulation. Various analogues within this class of chemistry can be tuned to the redox potential for selective targeting of cancer cell types. Background: Iron is an essential...
Published: 1/19/2023   |   Inventor(s): Elisa Tomat, Zoufeng Xu
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences
MC4R Selective Ligand for Obesity and Alzheimer’s Disease Prevention
This technology is a novel peptide that has been shown to be a potent MC4R selective antagonist. It is a potential therapeutic for cognitive loss and obesity. Background: The challenges of neurodegradation, Alzheimer’s disease, and obesity have been shown to have some similar molecular signatures that contribute to disease and have thus created...
Published: 9/26/2022   |   Inventor(s): Minying Cai, Victor Hruby
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Healthcare Portfolios > Diabetes, Metabolism, Endocrinology & Obesity, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules
An Alternative Mode of RNA Interference Triggered through Feeding Synthetic RNAs that are Processed into piRNAs
This invention describes a new method of the widely-used RNA interference technique with potential clinical and research applications. Background: RNA interference is a commonly used method to knockdown or “silence” genes. This is typically done using small interfering RNA (siRNA) probes designed with specificity to bind and tag certain...
Published: 10/25/2022   |   Inventor(s): Judith Brown, Mosharrof Hossain Mondal, Jorge Rafael Paredes Montero, Alex Flynt
Keywords(s):  
Category(s): Technology Classifications > Agriculture & Horticulture, Technology Classifications > Agriculture & Horticulture > Crop Improvement, Technology Classifications > Life Sciences > RNAi/siRNA, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Therapeutics
Use of DNA Containing Specific Sequences to Prevent Neisseria Gonorrhoeae Infection
This invention encompasses an antimicrobial that can treat disease caused by the pathogen Neisseria Gonorrhoeae (Ngo). The compounds described can be incorporated into commercially available personal lubricants for individual use. Background: N. gonorrhoeae (Ngo) causes over 160 million new cases of gonorrhea each year globally; in 2018, it caused...
Published: 1/23/2023   |   Inventor(s): Magdalene So, Maria Rendon
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Infectious Diseases
Genes and Polypeptides of Neisseria Musculi that can be used to Evaluate Vaccines and Anti-Bacterial Compounds against Infection by Pathogenic Neisseria Species
A set of Neisseria musculi (Nmus) genes have been identified which promote Nmus infection and persistence in its natural host, the mouse. These genes have never been described before, so the in-host function of their encoded proteins is unknown. These genes are present in the human pathogenic Neisseria, N. meningitidis and N. gonorrhoeae. These genes...
Published: 9/1/2022   |   Inventor(s): Magdalene So, Katherine Rhodes, Maria Rendon
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Life Sciences > Therapeutics
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