Search Results - technology+classifications+%3e+life+sciences+%3e+therapeutics

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Small Molecule Chaperones of CLN1 and CLN2
The inventors here have identified small molecules that target palmitoyl-protein thioesterase 1 (PPT1), tripeptidyl peptidase 1 (TPP1), enzymes that are deficient and less active in Batten disease or Neuronal Ceroid Lipofuscinosis. The CLN1 and CLN2 genes regulate the production of these enzymes, respectively. Background: Batten Disease, or Neural...
Published: 9/6/2022   |   Inventor(s): May Khanna, Jena Lipsa
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Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
Tetrazolium-Based Pro-Chelators as New Anticancer Agents
This invention comprises a class of tetrazolium-based prochelators for targeting and binding intracellular iron for selective cancer cell antiproliferation or other iron dysregulation. Various analogues within this class of chemistry can be tuned to the redox potential for selective targeting of cancer cell types. Background: Iron is an essential...
Published: 8/11/2022   |   Inventor(s): Elisa Tomat, Zoufeng Xu
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Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences
MC4R Selective Ligand for Obesity and Alzheimer’s Disease Prevention
This technology is a novel peptide that has been shown to be a potent MC4R selective antagonist. It is a potential therapeutic for cognitive loss and obesity. Background: The challenges of neurodegradation, Alzheimer’s disease, and obesity have been shown to have some similar molecular signatures that contribute to disease and have thus created...
Published: 7/27/2022   |   Inventor(s): Minying Cai, Victor Hruby
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Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Healthcare Portfolios > Diabetes, Metabolism, Endocrinology & Obesity, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules
An Alternative Mode of RNA Interference Triggered through Feeding Synthetic RNAs that are Processed into piRNAs
This invention describes a new method of the widely-used RNA interference technique with potential clinical and research applications. Background: RNA interference is a commonly used method to knockdown or “silence” genes. This is typically done using small interfering RNA (siRNA) probes designed with specificity to bind and tag certain...
Published: 5/20/2022   |   Inventor(s): Judith Brown, Mosharrof Hossain Mondal, Jorge Rafael Paredes Montero, Alex Flynt
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Category(s): Technology Classifications > Agriculture & Horticulture, Technology Classifications > Agriculture & Horticulture > Crop Improvement, Technology Classifications > Life Sciences > RNAi/siRNA, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Therapeutics
Use of DNA Containing Specific Sequences to Prevent Neisseria Gonorrhoeae Infection
This invention encompasses an antimicrobial that can treat disease caused by the pathogen Neisseria Gonorrhoeae (Ngo). The compounds described can be incorporated into commercially available personal lubricants for individual use. Background: N. gonorrhoeae (Ngo) causes over 160 million new cases of gonorrhea each year globally; in 2018, it caused...
Published: 5/6/2022   |   Inventor(s): Magdalene So, Maria Rendon
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Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Infectious Diseases
Genes and Polypeptides of Neisseria Musculi that can be used to Evaluate Vaccines and Anti-Bacterial Compounds against Infection by Pathogenic Neisseria Species
A set of Neisseria musculi (Nmus) genes have been identified which promote Nmus infection and persistence in its natural host, the mouse. These genes have never been described before, so the in-host function of their encoded proteins is unknown. These genes are present in the human pathogenic Neisseria, N. meningitidis and N. gonorrhoeae. These genes...
Published: 5/6/2022   |   Inventor(s): Magdalene So, Katherine Rhodes, Maria Rendon
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Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Life Sciences > Therapeutics
Method of Treating Acute Lung Injury Using Sphingosine 1 Phosphate Analogs Or Sphingosine 1 Phosphate Receptor Agonists
This invention describes a method to treat and reduce the risk for acute lung injury (ALI) associated with radiation, infection, trauma, and other environmental-related lung injury. The method described involves the administration of analogs or derivatives of a Sphingosine 1 Phosphate (S1P) receptor agonists that have similar properties of S1P that...
Published: 5/5/2022   |   Inventor(s): Joe Garcia, Steven Dudek
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Category(s): Technology Classifications > Life Sciences > Therapeutics
Inhibition of SGK1 via a Synthetic Protein-Protein Interaction Inhibitory Peptide
This technology is a peptide that binds serum glucocorticoid kinase 1 (SGK1) to prevent binding to glucocorticoid-inducible leucine zipper protein (GILZ). The interaction between GILZ-SGK1 protects SGK1 from degradation, and the peptide developed prevents this interaction allowing for SGK1 degradation and decreased SGK1-mediated cardiac hypertrophy,...
Published: 1/18/2022   |   Inventor(s): Erik Blackwood, Christopher Glembotski
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Category(s): Technology Classifications, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences
Small Molecule Mixed Agonist/Antagonist for Opioid Receptors for Anti-Addiction and/or Pain Therapy
This invention provides compositions and method of pain treatment using a mixture of an opioid receptor agonist in combination with an adrenoreceptor modulator compound. The opioid receptor agonist may be a clinically-used drug, and the adrenoreceptor modulator compound is a novel small molecule. ­Proof-of-concept testing in animals has shown...
Published: 1/4/2022   |   Inventor(s): Iman Daryaei, John Streicher, Abigail Schwarz
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Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
Discovery of an eIF4A Inhibitor with a Novel Mechanism of Action
This invention describes an inhibitor of eIF4A, which is a validated cancer drug target. The inventors describe a novel mechanism by which this inhibitor works. Background: Oncogenic, or cancer-causing pathways have long been challenging drug targets, especially for complex cancers. One protein complex called eIF4F is key to select oncogenic pathways...
Published: 12/6/2021   |   Inventor(s): Eli Chapman, Christopher Zerio
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Category(s): Technology Classifications, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Healthcare Portfolios > Oncology
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