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Peptides to Treat SARS-CoV, Pulmonary Hypertension and other Pulmonary Vascular Diseases
This innovation is centered around a peptide designed to interrupt the action of a protein called Aminopeptidase N (APN). This peptide functions as an antagonist or inhibitor, binding to the intracellular portion of APN. The primary focus of this technology is to treat pulmonary arterial hypertension (PAH) and viral infections, including COVID-19. PAH...
Published: 10/11/2023
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Inventor(s): Joel James, Ruslan Rafikov
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Life Sciences > Therapeutics
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A Method of Treating Fibrosis and Cancer across Organ Systems
This technology is directed to a method of treating fibrosis and cancer comprising targeting circulating cells. Researchers identified mechanoresponsive myeloid subpopulations present in fibrotic and healthy tissue. Certain subpopulations of circulating cells have been implicated in the processes of cancer and fibrosis. These subpopulations are subsequently...
Published: 10/11/2023
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Inventor(s): Geoffrey Gurtner, Kellen Chen
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Category(s): Technology Classifications > Healthcare Portfolios > Wound Healing, Technology Classifications > Life Sciences > Therapeutics
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Broad Spectrum Inhibitors against Viral Methyltransferases
This innovation is a universal high throughput screening (HTS) assay to identify inhibitors targeting a binding site of viral methyltransferases (MTases) with a methyl donor. The inventors developed a fluorescence polarization (FP)-based HTS assay to target reference MTases, an essential enzyme to methylate the 5’-cap of viral RNA genome on SARS-CoV-2...
Published: 11/16/2023
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Inventor(s): Hongmin Li, Zhong Li
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Infectious Diseases
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Iron Targeting to Halt Proliferation in Malignant Cells
This invention comprises a class of tetrazolium-based prochelators for targeting and binding intracellular iron and thereby interfere in cancer cell proliferation or other iron dysregulation. The redox potential of various analogues within this class of compounds can be tuned for targeting of cancer cells. Following cellular uptake, the tetrazolium...
Published: 11/16/2023
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Inventor(s): Elisa Tomat, Yu-Shien Sung
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics
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Novel Modalities for the Treatment of Cryptococcal Meningitis
This invention is the repurposing of oxfendazole, an FDA-approved veterinary anthelmintic benzimidazole and its novel oral bioavailability enhancing formulations for the oral treatment of cryptococcal meningitis. The oxfendazole ionic liquid containing nano formulations can lead to the development of low-cost oral treatment for cryptococcal meningitis.
Background:...
Published: 11/16/2023
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Inventor(s): Abhijit Date, Yogesh Sutar, Kirsten Nielsen
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Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Drug Delivery
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Biocompatible Ionic Liquids for Improving Delivery of Therapeutic Agents
This invention relates to three types of ionic liquids (ILs) that will improve the delivery of a diverse array of therapeutic agents. The first type of ILs consists of a drug as either cation or anion and a biocompatible counterion to improve the aquas or solubility and permeability of drugs and to facilitate the incorporation of these ILs into various...
Published: 11/16/2023
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Inventor(s): Abhijit Date, Yogesh Sutar
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Therapeutics
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Cosmoceutical Gases-As-Drugs: Planet Atmosphere Gases Enwrapping into Soft Materials for Precise Medical Therapy
This invention enables the discovery of planetary gases and volatiles for medical gas therapy by using novel gas marbles delivery systems for tissue targeting or systemic and controlled deliveries. Gas and liquid “entrapping” into gel or foam materials have been formulated for various applications including drug delivery. This invention...
Published: 11/16/2023
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Inventor(s): Frederic Zenhausern, Joellen Russell, Michael Gordon, Justin Moser, Marta Sowinski, Ashlee Harris, Zhu Zhao, Matthew Barrett
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Category(s): Technology Classifications > Healthcare Portfolios > Anesthesiology, Technology Classifications > Life Sciences > Therapeutics
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Mechanism of Tissue Regeneration
This invention is a biodegradable patch seeded with human neonatal dermal fibroblasts and human induced pluripotent stem cell derived cardiomyocytes which helps regenerate endogenous cardiomyocytes in adult murine, rat, and swine models of myocardial infarction as a cause of chronic heart failure (CHF). This invention details changes in specific gene...
Published: 5/24/2023
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Inventor(s): Steven Goldman, Jennifer Koevary, Jordan Lancaster, Jordan Fink, Adrian Grijalva
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Category(s): Technology Classifications > Healthcare Portfolios > Regenerative Medicine / Tissue Engineering, Technology Classifications > Life Sciences > Therapeutics
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Druggable Formulation for Mu/Delta Opioid Antagonist for Enhancing Pain Therapy and Treatment of Opioid Withdrawal
This invention provides compositions and method of pain treatment using a mu/delta opioid receptor heterodimer (MDOR) antagonist which has improved druggability by nanoformulation and/or glycosylation to increase their bioavailability and efficacy. These modified antagonists and formulations provide for enhancement of opioid agonist therapy's antinociceptive...
Published: 7/6/2023
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Inventor(s): John Streicher, Robin Polt, Lajos Szabo, Wafaa Alabsi, Parthasaradhi Reddy Tanguturi
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Neurology
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A Recombinant Protein to Restore the Anti-Cancer Activity of Immune Cells
This invention is a recombinant protein that is designed to restore the activity of immune cells that have been exhausted in patients with cancer. This invention focuses specifically on the restoration of the anti-cancer activity of immune cells, in particular natural killer (NK) cells.
Background:
Immune cell-based therapies are a widely utilized...
Published: 11/16/2023
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Inventor(s): Youngwook Won, Seungmin Han, David Bull
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Oncology
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