Search Results - technology+classifications+%3e+research+tools+%3e+reagents

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Intracellular Delivery of Small Molecule Reactive Ligands for Bioconjugation
A protected small molecule probe is delivered intracellularly and subsequently releases an aryl diazonium ion for use as a bioconjugation agent or drug delivery agent. This technology enables a novel chemical probe for observing intact biological cells. Background: Selectivity in biological systems comes from a complex interplay of location, interactions,...
Published: 5/24/2022   |   Inventor(s): John Jewett, Natasha Cornejo, Bismark Amofah, Lindsay Guzman, W Mudiyanselage Anjalee Wijetunge
Keywords(s):  
Category(s): Technology Classifications > Materials > Chemicals, Technology Classifications > Research Tools > Reagents
A Method for Characterizing Adeno-Associated Virus Capsids with Thermal Unfolding and Mass Spectrometry
This invention describes modulating the temperature of the solution in an electrospray needle prior to charge-detection mass spectrometry (CD/MS) to enable discrimination between the individual stabilities of multiple forms of viral particles that may be present in an AAV preparation. This increased discrimination provides the operator with a unique...
Published: 5/23/2022   |   Inventor(s): Michael Marty, Marius Kostelic
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Category(s): Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Veterinary Medicine > Therapeutics & Vaccines, Technology Classifications > Research Tools > Reagents, Technology Classifications > Materials > Biomaterials
Demultiplex Single-Cell Sequencing Data using DNA Barcode Dyes
This technology applies to single cell RNA sequencing data that is created in parallel (multiplexed) to speed the process. Once the multiplexed data exists, it needs to be recombined into one set (demultiplexed) to be useful. This technology is a new demultiplexing technique that uses dyes combined with DNA barcodes, simplifying the demultiplexing process. Background: RNA...
Published: 2/10/2022   |   Inventor(s): Jared Churko
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Reagents, Technology Classifications > Research Tools > Screening assays
Tunable Fluorescent Indolizine Tetracycles
This technology is tunable fluorescent probes that are able to span the colors of the rainbow. The main benefit of this technology is that it can be prepared in only one or two steps; as opposed to the five to seven steps it would normally take. Not only is this technology quicker, but the cost of goods is also more reasonable and compares very favorably...
Published: 1/18/2022   |   Inventor(s): Christopher Hulme, Nathan Bedard
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Category(s): Technology Classifications, Technology Classifications > Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Reagents
Metal Organic Frameworks for Scintillation Detection of Low Energy Radionuclides
Scintillating metal-organic framework (MOF) particles provide enhanced and robust low-energy β emission sensing in aqueous systems. In addition to being stable and dispersive in aqueous solutions, the scintillating -MOFs are stable and functional in a wide range of organic and aqueous-organic systems and uniquely allow control of excitonic transport...
Published: 10/25/2021   |   Inventor(s): Craig Aspinwall, Chen-Yi Ke, Minhui Han, Brian Zacher
Keywords(s):  
Category(s): Technology Classifications > Materials > Nanomaterials, Technology Classifications > Materials > Chemicals, Technology Classifications > Materials > Medical Devices > Diagnostic, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Reagents
Bioconjugation and Protein Labeling with Photo-Initiated, Bench-Stable, Water-soluble Triazene Reagents
Triazenes and methods of producing diazonium species from said traizenes using ultraviolet (UV) light, which provide a fast, easy, stable, scalable, and selectively-triggerable means of modifying aromatic nucleophiles, including those on protein surfaces. The invention includes triazenes for use as bioconjugates, e.g., for use in protein modification,...
Published: 6/8/2021   |   Inventor(s): Garrett Davis, John Jewett
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Reagents
Small Molecule Scaffolds for use as Protein Tags, Probes, and Conjugates
This invention relates to a molecular delivery system containing a chemical scaffold based on triazabutadiene, which can release a chemical species containing (a) a reactive diazaonium functional group covalently linked to (b) any number of aryl groups using a simple Suzuki coupling. The chemical species so released may be a drug, probe, tag, or conjugate....
Published: 7/1/2020   |   Inventor(s): Abigail Shepard, John Jewett
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Category(s): Technology Classifications > Materials > Chemicals, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Protein, Technology Classifications > Research Tools > Reagents, Technology Classifications > Research Tools > Screening assays
Shelf-Stable Reagent for Bioconjugation and Protein Labeling
This invention is a new class of amine-reactive, water-stable, small molecules for use as probes, reagents, or bioconjugates. These molecules are lysine-reactive and conjugate quickly without the need for coupling reagents or catalysts. The molecules are simple to synthesize and purify, with high yields. These materials selectively react with lysine...
Published: 3/17/2020   |   Inventor(s): John Jewett, Garrett Davis, Holly Sofka
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Protein, Technology Classifications > Research Tools > Reagents, Technology Classifications > Life Sciences > Diagnostics
Novel Method for Synthesis of Indoles
This invention describes a novel method of generating heterocyclic compounds via a 3+2 annulation. This method does not require expensive reagents and, in some instances, can be completed in a chiral manner. Background: Existing methods to synthesize heterocycles usually require multiple steps, metal catalysts, and/or relatively expensive reagents....
Published: 10/30/2015   |   Inventor(s): Jon Njardarson, Edon Vitaku
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Materials > Ceramics, Technology Classifications > Materials > Biocompatible, Technology Classifications > Materials > Medical Devices > Therapeutic, Technology Classifications > Research Tools > Protein, Technology Classifications > Research Tools > Reagents
Stage-Specific mRNA from Maize Endosperm for Identification of Protein-Protein Interactions
Stage-Specific mRNA from Maize Endosperm for Identification of Protein-Protein Interactions
Published: 5/7/2015   |   Inventor(s): Ramin Yadegari, Guosheng Li, Junpeng Zhan
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Category(s): Technology Classifications > Agriculture & Horticulture, Technology Classifications > Research Tools > Reagents