Search Results - technology+classifications

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Mini-Sensor Suspension System for Supine CO2 Monitoring
A multi-CO2-mini-sensor-based monitoring system has been developed to measure the CO2 concentration of human respiratory gas around a subject’s face while the subject is in the supine position. According to the collected data, the system supports further analysis of human physical conditions such as sleep stage and quality. The mini-CO2 sensor...
Published: 9/7/2022   |   Inventor(s): Yijie Chen, Md Tariqul Islam, Young-Jun Son, Esther Sternberg
Keywords(s):  
Category(s): Technology Classifications, Technology Classifications > Healthcare Portfolios, Technology Classifications > Healthcare Portfolios > Respiratory & Pulmonary, Technology Classifications > Materials > Medical Devices
Methods and Materials for Modulating Construct Wear Due to Cyclic Loading
Rethinking the structural organization of a polymer is a normally forgone solution for improving polymer flexibility. Here, the inventors have created four improved ways to manufacture polymers. The first is to create it at its mid-stress point, the second is to make the polymer with a shifting neutral axis, the third method uses polymers to provide...
Published: 8/31/2022   |   Inventor(s): Marvin Slepian, Syed Hossainy
Keywords(s):  
Category(s): Technology Classifications, Technology Classifications > Materials > Biocompatible, Technology Classifications > Materials > Medical Devices, Technology Classifications > Healthcare Portfolios
Tetrazolium-Based Pro-Chelators as New Anticancer Agents
This invention comprises a class of tetrazolium-based prochelators for targeting and binding intracellular iron for selective cancer cell antiproliferation or other iron dysregulation. Various analogues within this class of chemistry can be tuned to the redox potential for selective targeting of cancer cell types. Background: Iron is an essential...
Published: 8/11/2022   |   Inventor(s): Elisa Tomat, Zoufeng Xu
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences
Small Molecule DYRK/CLK Inhibitors and Uses Thereof
This invention is a new composition of matter spanning a 6,6-fused chemotype. The 6,6-analogs display strong inhibitory activity across protein kinases such as the DYRK family, including DYRK1A, DYRK2, and DYRK3, along with inhibiting CLK. The dual DYRK/CLK inhibitors have displayed activity in 3-D organoid models of glioblastoma. It is subsequently...
Published: 6/27/2022   |   Inventor(s): Christopher Hulme, Alessandra Fistrovich, Yeng Jeng Shaw, Sourav Banerjee, Curtis Thorne, Nathan Bedard, Carly Cabel
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Category(s): Technology Classifications, Technology Classifications > Healthcare Portfolios
A Small Molecule Kinase Inhibitor that Regulates RNA Degradation and Inhibits Tumor Growth and Invasion
This invention describes a novel potential therapeutic for several cancers that inhibits tumor growth and invasion by regulating RNA degradation. Background: There have long been attempts to find new cellular mechanisms that can be targeted for a wide range of cancers without the notable and significant toxic effects of existing therapies like chemotherapy...
Published: 6/16/2022   |   Inventor(s): Andrew Kraft, Koichi Okumura, Wei Wang, Giri Gnawali
Keywords(s):  
Category(s): Technology Classifications, Technology Classifications > Healthcare Portfolios
Vascular Plug
This technology is a small silicon item that is designed to fit in blood vessels to stop blood loss by plugging the vessels to allow for ligation of the vessel during surgical procedures. Prototypes of two durometers have been made. These plugs will come in slightly varied sizes to allow them to fit in any vessel. Background: The World Health Organization...
Published: 5/25/2022   |   Inventor(s): Craig Weinkauf, Scott DeRigne
Keywords(s):  
Category(s): Technology Classifications, Technology Classifications > Life Sciences, Technology Classifications > Materials > Medical Devices
Sex and APOE Genotype Precision Therapeutic Targets Discovery for Alzheimer’s disease
­Title: Nutraceutical Formula for Alzheimer's and other Neurodegenerative Diseases Invention: This technology encompasses a formulation for patient subgroup-specific supplement for the treatment and therapy of Alzheimer's and other neurodegenerative diseases. These formulations can range in delivery method (food, drink, pill) and can be...
Published: 5/5/2022   |   Inventor(s): Rui Chang, Roberta Brinton, Kuixi Zhu, Rima Kaddurah-Daouk
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Category(s): Technology Classifications, Technology Classifications > Healthcare Portfolios, *Medical
HIF-1alpha Phospho-T455 Antibody
­This invention relates to a polyclonal antibody against a novel phosphorylation site that is known to be correlated with increased tumor growth. Specifically, the antibody targets a phosphorylation site on HIF-1α which is controlled by PIM kinases. This invention can be used not only as a therapeutic against cancer but also potentially as...
Published: 4/19/2022   |   Inventor(s): Noel Warfel
Keywords(s):  
Category(s): Technology Classifications > Research Tools, Technology Classifications, Technology Classifications > Healthcare Portfolios > Oncology
Innovative Approaches to Optimize the Therapeutic Benefits of Autophagy Inhibition
This technology consists of novel, soluble compounds that are to be used to inhibit autophagy that can lead to pathogenesis of many different diseases and health conditions. Background: Autophagy is the process that regulates the degradation of overabundant malfunctioning cellular components. Autophagy is vital for maintaining cell renewal processes;...
Published: 2/22/2022   |   Inventor(s): Jennifer Carew, Steffan Nawrocki, Wei Wang
Keywords(s):  
Category(s): Technology Classifications, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Small Molecules
A Novel Pan-T-Type Calcium Channel Modulator that alleviates Tonic, Neuropathic and Inflammatory Pain
This invention describes a non-opioid method to treat pain using a novel T-type calcium channel blocker. Background: Current treatments for many types of pain typically include opioid painkillers, which pose a significant risk of addiction and overdose in patients, creating a demand for a treatment with less risk and less side-effects. In neuropathic,...
Published: 2/10/2022   |   Inventor(s): Rajesh Khanna, Jun Wang
Keywords(s):  
Category(s): Technology Classifications, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Small Molecules
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