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Intracellular Delivery of Small Molecule Reactive Ligands for Bioconjugation
A protected small molecule probe is delivered intracellularly and subsequently releases an aryl diazonium ion for use as a bioconjugation agent or drug delivery agent. This technology enables a novel chemical probe for observing intact biological cells. It builds on previous IP developed by Jewett laboratory for protection, as a class of chemistry enabling...
Published: 4/3/2023
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Inventor(s): John Jewett, Natasha Cornejo, Bismark Amofah, Lindsay Guzman, W Mudiyanselage Anjalee Wijetunge, Indraneel Ghosh, Danielle Johnson, Abigail Shepard
Keywords(s):
Category(s): Technology Classifications > Materials > Chemicals, Technology Classifications > Research Tools > Reagents
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Bioconjugation and Protein Labeling with Photo-Initiated, Bench-Stable, Water-Soluble Triazene Reagents
Triazenes and methods of producing diazonium species from said triazenes using ultraviolet (UV) light, which provide a fast, easy, stable, scalable, and selectively-triggerable means of modifying aromatic nucleophiles, including those on protein surfaces. The invention includes triazenes for use as bioconjugates, e.g., for use in protein modification,...
Published: 4/3/2023
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Inventor(s): Garrett Davis, John Jewett
Keywords(s):
Category(s): Technology Classifications > Research Tools > Reagents
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Protein Structure Analysis using One-Step Tyrosine Conjugation
This invention includes methods and systems for detecting, comparing, or evaluating proteins in an folded conformation, a particular bound state, or an aggregate state, and methods and systems for comparing amounts of labeling of a protein in a natural or control conformation and a denatured conformation. The methods of this invention may be used for...
Published: 4/3/2023
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Inventor(s): Jacob Schwartz, John Jewett, Mahta Moinpour
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Healthcare Portfolios > Orphan Diseases, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Protein
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Shelf-Stable Reagent for Bioconjugation and Protein Labeling
This invention is a new class of amine-reactive, water-stable, small molecules for use as probes, reagents, or bioconjugates. These molecules are lysine-reactive and conjugate quickly without the need for coupling reagents or catalysts. The molecules are simple to synthesize and purify, with high yields. These materials selectively react with lysine...
Published: 4/3/2023
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Inventor(s): John Jewett, Garrett Davis, Holly Sofka
Keywords(s):
Category(s): Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Protein, Technology Classifications > Research Tools > Reagents, Technology Classifications > Life Sciences > Diagnostics
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pH Releasable Linkers for Drug Delivery, Imaging, or Diagnostics
This technology describes water-soluble triazabutadienes as cross-linkers to and protecting groups for small-molecule therapeutics or fluorescent moities. Upon changes in chemical conditions, triazabutadienes release a highly reactive diazonium species, enabling targeted delivery of the cross-linked molecule.
Background:
Cross linking is becoming...
Published: 4/3/2023
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Inventor(s): John Jewett, Flora Kimani
Keywords(s): diagnostic tool
Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Drug Delivery
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Triazabutadienes as Cleavable Protein Linkers
This technology describes water-soluble triazabutadienes as cleavable cross linkers. Upon changes in chemical conditions, triazabutadienes release a highly reactive diazonium species, enabling delivery of the cross-linked molecule.
Background:
Cross linking is becoming a valuable practice in chemistry, including for life science applications, with...
Published: 4/3/2023
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Inventor(s): John Jewett, Lindsay Guzman, Flora Kimani, Brandon Cornali
Keywords(s):
Category(s): Technology Classifications > Materials > Polymers
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Quantitative Detection of Protein Misfolding or Aggregation by Chemical Labeling
This invention describes methods and systems for detecting, comparing, or evaluating proteins in a folded conformation, a particular bound state, or an aggregate state, and methods and systems for comparing amounts of labeling of a protein in a natural or control conformation and a denatured conformation. The methods of this invention may be used for...
Published: 4/3/2023
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Inventor(s): Jacob Schwartz, John Jewett, Mahta Moinpour, Mehrdad Shadmehr
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Medical Devices > Diagnostic
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Underwater Adhesives
This technology provides a method for underwater adhesion through the use of a masked compound that, when exposed to water, forms covalent bonds with surfaces containing phenols.
Background:
It is extremely difficult to repair cracked or broken surfaces that are exposed to water (i.e. boat hulls, swimming pools, human tissues, etc.) without the...
Published: 4/3/2023
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Inventor(s): John Jewett
Keywords(s):
Category(s): Technology Classifications > Engineering & Physical Sciences > Industrial & Manufacturing > Construction, Technology Classifications > Healthcare Portfolios > Wound Healing, Technology Classifications > Materials > Composites
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Water-soluble Triazabutadienes that Release Diazonium Species upon Physiologically Relevant Protonation
This technology is a class of water-soluble triazabutadienes that deposit desired molecular diazonium salt cargo in a pH sensitive and reactive manner. The triazabutadiene is stable at higher pH values, allowing the decomposition to be controlled.
Background:
Certain viruses and pathogens, such as the dengue virus (DENV), have pH sensitive pathways...
Published: 4/3/2023
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Inventor(s): John Jewett, Flora Kimani
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Drug Delivery
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Enzymatically Released Aryl Diazonium Ions
This invention is the discovery of triazebutadienes that rapidly release aryl diazonium ions at neutral pH with a half-life of approximately one minute.
Background:
In 2015, the global protein therapeutics market grew to nearly $174.7 billion due to trends in targeted therapies that resulted in fewer side effects. Monoclonal antibodies and biologics...
Published: 4/3/2023
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Inventor(s): John Jewett, Lindsay Guzman, Bereketab Mehari, Jie He
Keywords(s):
Category(s): Technology Classifications > Life Sciences
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