Search Results - john+jewett

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Intracellular Delivery of Small Molecule Reactive Ligands for Bioconjugation
A protected small molecule probe is delivered intracellularly and subsequently releases an aryl diazonium ion for use as a bioconjugation agent or drug delivery agent. This technology enables a novel chemical probe for observing intact biological cells. Background: Selectivity in biological systems comes from a complex interplay of location, interactions,...
Published: 5/24/2022   |   Inventor(s): John Jewett, Natasha Cornejo, Bismark Amofah, Lindsay Guzman, W Mudiyanselage Anjalee Wijetunge
Keywords(s):  
Category(s): Technology Classifications > Materials > Chemicals, Technology Classifications > Research Tools > Reagents
Bioconjugation and Protein Labeling with Photo-Initiated, Bench-Stable, Water-soluble Triazene Reagents
Triazenes and methods of producing diazonium species from said traizenes using ultraviolet (UV) light, which provide a fast, easy, stable, scalable, and selectively-triggerable means of modifying aromatic nucleophiles, including those on protein surfaces. The invention includes triazenes for use as bioconjugates, e.g., for use in protein modification,...
Published: 6/8/2021   |   Inventor(s): Garrett Davis, John Jewett
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Reagents
Protein Structure Analysis using One-Step Tyrosine Conjugation
This invention includes methods and systems for detecting, comparing, or evaluating proteins in an folded conformation, a particular bound state, or an aggregate state, and methods and systems for comparing amounts of labeling of a protein in a natural or control conformation and a denatured conformation. The methods of this invention may be used for...
Published: 12/2/2020   |   Inventor(s): Jacob Schwartz, John Jewett, Mahta Moinpour
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Healthcare Portfolios > Orphan Diseases, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Protein
Small Molecule Scaffolds for use as Protein Tags, Probes, and Conjugates
This invention relates to a molecular delivery system containing a chemical scaffold based on triazabutadiene, which can release a chemical species containing (a) a reactive diazaonium functional group covalently linked to (b) any number of aryl groups using a simple Suzuki coupling. The chemical species so released may be a drug, probe, tag, or conjugate....
Published: 7/1/2020   |   Inventor(s): Abigail Shepard, John Jewett
Keywords(s):  
Category(s): Technology Classifications > Materials > Chemicals, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Protein, Technology Classifications > Research Tools > Reagents, Technology Classifications > Research Tools > Screening assays
Shelf-Stable Reagent for Bioconjugation and Protein Labeling
This invention is a new class of amine-reactive, water-stable, small molecules for use as probes, reagents, or bioconjugates. These molecules are lysine-reactive and conjugate quickly without the need for coupling reagents or catalysts. The molecules are simple to synthesize and purify, with high yields. These materials selectively react with lysine...
Published: 3/17/2020   |   Inventor(s): John Jewett, Garrett Davis, Holly Sofka
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Protein, Technology Classifications > Research Tools > Reagents, Technology Classifications > Life Sciences > Diagnostics
pH Releasable Linkers for Drug Delivery, Imaging, or Diagnostics
This technology describes water-soluble triazabutadienes as cross-linkers to and protecting groups for small-molecule therapeutics or fluorescent moities. Upon changes in chemical conditions, triazabutadienes release a highly reactive diazonium species, enabling targeted delivery of the cross-linked molecule. Background: Cross linking is becoming...
Published: 1/27/2020   |   Inventor(s): John Jewett, Flora Kimani
Keywords(s): diagnostic tool
Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Drug Delivery
Triazabutadienes as Cleavable Protein Linkers
This technology describes water-soluble triazabutadienes as cleavable cross linkers. Upon changes in chemical conditions, triazabutadienes release a highly reactive diazonium species, enabling delivery of the cross-linked molecule. Background: Cross linking is becoming a valuable practice in chemistry, including for life science applications, with...
Published: 4/26/2018   |   Inventor(s): John Jewett, Lindsay Guzman, Flora Kimani, Brandon Cornali
Keywords(s):  
Category(s): Technology Classifications > Materials > Polymers
Quantitative Detection of Protein Misfolding or Aggregation by Chemical Labeling
This invention describes methods and systems for detecting, comparing, or evaluating proteins in a folded conformation, a particular bound state, or an aggregate state, and methods and systems for comparing amounts of labeling of a protein in a natural or control conformation and a denatured conformation. The methods of this invention may be used for...
Published: 5/31/2017   |   Inventor(s): Jacob Schwartz, John Jewett, Mahta Moinpour, Mehrdad Shadmehr
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Materials > Medical Devices > Diagnostic, Technology Classifications > Healthcare Portfolios > Neurology
Underwater Adhesives
This technology provides a method for underwater adhesion through the use of a masked compound that, when exposed to water, forms covalent bonds with surfaces containing phenols. Background: It is extremely difficult to repair cracked or broken surfaces that are exposed to water (i.e. boat hulls, swimming pools, human tissues, etc.) without the...
Published: 5/31/2017   |   Inventor(s): John Jewett
Keywords(s):  
Category(s): Technology Classifications > Engineering & Physical Sciences > Industrial & Manufacturing > Construction, Technology Classifications > Healthcare Portfolios > Wound Healing, Technology Classifications > Materials > Composites
Water-soluble Triazabutadienes that Release Diazonium Species upon Physiologically Relevant Protonation
This technology is a class of water-soluble triazabutadienes that deposit desired molecular diazonium salt cargo in a pH sensitive and reactive manner. The triazabutadiene is stable at higher pH values, allowing the decomposition to be controlled. Background: Certain viruses and pathogens, such as the dengue virus (DENV), have pH sensitive pathways...
Published: 5/4/2017   |   Inventor(s): John Jewett, Flora Kimani
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Drug Delivery
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