Methods and Compositions for Rapidly Replacing Cardiac Myosin Binding Protein-C in Sarcomeres

Case ID:

This technology is designed to relate to myosin binding protein-C (MyBP-C), more particularly to methods and compositions for modifying MyBP-C in sarcomeres, e.g., protein engineering for studying MyBP-C in sarcomeres. It is an objective of the present invention to provide methods and compositions that allow for a single gene-edited mouse model that allows for rapid exchange of new combinations of modified or mutant MyBP-C.


According to the CDC, one person dies every 36 seconds in the United States from cardiovascular disease. Also, heart disease is the leading cause of death for men, women, and people from most ethnic groups in the United States. The heart contracts and converts chemical energy from ATP hydrolysis into mechanical force. The heart must work correctly for blood to be pumped efficiently to the body. Myosin binding protein-C modulates the productivity of the heart and allows it to work more efficiently under stress. 


  • Clinical setting
  • Cardiac research
  • Cardiac facilities


  • Effective
  • Targets the many issues that lead to heart disease
Patent Information:
Contact For More Information:
Mitch Graffeo
Sr. Licensing Manager - COM-T
The University of Arizona
Lead Inventor(s):
Samantha Harris