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Novel Multi-Omics Aging Clock
­A multi-omics clock analyzes multiple layers of omics data with machine learning to predict remaining lifespan of mammals, particularly for animal model studies. Large omics data sets may be used from combinations of genomics, proteomics, lipids, etc. available from blood or other simple sample collection. This tool can robustly capture changes...
Published: 9/13/2022   |   Inventor(s): George Sutphin, Samuel Freitas, Megha Padi, Chen Chen
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Simulators and Modeling Tools
A New Mouse Strain (Zip14flox/flox (Slc39a14flox/flox)
University of Arizona researchers have generated a new Zip14flox/flox mouse strain. The strain can be used to generate Zip14 knockout in a tissue-specific manner and is useful to examine tissue-specific function of Zip14. Applications: Functional analysis of Zip14
Published: 7/15/2022   |   Inventor(s): Ningning Zhao
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Animal Models
Cyp2f2 Knock-Out Mouse
This technology is a Cyp2f2-null mouse model that is valuable for studying the role of CYP2F2 in the metabolism and toxicity of numerous foreign compounds that can cause airway injury and disease. Background: CYP2F enzymes are abundantly expressed in the respiratory tract and are active towards many foreign compounds coming from environmental chemicals,...
Published: 7/15/2022   |   Inventor(s): Xinxin Ding
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Animal Models
Novel Knockout Model Of ER-Beta in Rat Neurons
This technology is one of a set of five rat models that is focused on the role of estrogen and its receptors within the brain. This specific rat model is an ER-beta-FloxP-Cre rat that has ER-beta knocked out specifically in neurons. Background: Progress in determining the role of estrogen and its receptors in the brain has been limited by the lack...
Published: 7/15/2022   |   Inventor(s): Roberta Brinton, Fei Yin, Tian Wang
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Life Sciences
Novel Knockout Model Of ER-Alpha in Rat Neurons
This technology is one of a set of five rat models that is focused on the role of estrogen and its receptors within the brain. This specific rat model is an ER-alpha-FloxP-Cre rat that has ER-alpha knocked out specifically in neurons. Background: Progress in determining the role of estrogen and its receptors in the brain has been limited by the lack...
Published: 7/15/2022   |   Inventor(s): Roberta Brinton, Fei Yin, Tian Wang
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Life Sciences
Novel Forebrain Neuron Specific CreERT2 Rat Model
This technology is one of a set of five rat models that is focused on the role of estrogen and its receptors. This specific rat model is forebrain neuron-specific CreERT2 rat model under the CamKII promoter. Background: Progress in determining the role of estrogen and its receptors in the brain has been limited by the lack of translatable rat models...
Published: 7/15/2022   |   Inventor(s): Roberta Brinton, Fei Yin, Tian Wang
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Life Sciences
Novel Conditional Knockout Model Of ER-Beta in Rats
This technology is one of a set of five rat models that is focused on the role of estrogen and its receptors within the brain. This specific rat model is an ER-beta FloxP rat that can be combined with tissue-specific Cre rats to generate ER-beta knockouts in any tissues expressing the estrogen receptor. Background: Progress in determining the role...
Published: 7/15/2022   |   Inventor(s): Roberta Brinton, Fei Yin, Tian Wang
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Life Sciences
Novel Conditional Knockout Model of ER-Alpha in Rats
This technology is one of a set of five rat models that is focused on the role of estrogen and its receptors within the brain. This specific rat model is an ER-alpha FloxP rat that can be combined with tissue-specific Cre rats to generate ER-alpha knockouts in any tissues expressing the estrogen receptor. Background: Progress in determining the role...
Published: 7/15/2022   |   Inventor(s): Roberta Brinton, Fei Yin, Tian Wang
Keywords(s):  
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Research Tools > Animal Models
Neurochemical Data Collection from In vivo Electrochemical Measurements
This invention allows for the collection of real-time chemical analysis of neurotransmitters in the brains of lab animals via rapid application of voltage with resulting current measurement from microelectrodes. Tiny carbon-fiber electrodes are implanted into the animal, and electrochemical measurements are recorded, providing information to relate...
Published: 7/15/2022   |   Inventor(s): Michael Heien, Christopher Atcherley
Keywords(s): accuracy
Category(s): Technology Classifications > Research Tools > Animal Models
Genetic Rat Model for Pulmonary Hypertension
This technology is a genetic rat model with a human mutation that allows for the study of pulmonary hypertension. This new model is ideal for studying the contribution of mitochondrial dysfunction that occurs in the development and progression of pulmonary hypertension. Background: Pulmonary hypertension (PH) is an increase in blood pressure within...
Published: 7/15/2022   |   Inventor(s): Ruslan Rafikov, Olga Rafikova
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Animal Models
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