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Demultiplex Single-Cell Sequencing Data using DNA Barcode Dyes
This technology applies to single cell RNA sequencing data that is created in parallel (multiplexed) to speed the process. Once the multiplexed data exists, it needs to be recombined into one set (demultiplexed) to be useful. This technology is a new demultiplexing technique that uses dyes combined with DNA barcodes, simplifying the demultiplexing process. Background: RNA...
Published: 2/10/2022   |   Inventor(s): Jared Churko
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Reagents, Technology Classifications > Research Tools > Screening assays
Metal Organic Frameworks for Scintillation Detection of Low Energy Radionuclides
Scintillating metal-organic framework (MOF) particles provide enhanced and robust low-energy β emission sensing in aqueous systems. In addition to being stable and dispersive in aqueous solutions, the scintillating -MOFs are stable and functional in a wide range of organic and aqueous-organic systems and uniquely allow control of excitonic transport...
Published: 10/25/2021   |   Inventor(s): Craig Aspinwall, Chen-Yi Ke, Minhui Han, Brian Zacher
Keywords(s):  
Category(s): Technology Classifications > Materials > Nanomaterials, Technology Classifications > Materials > Chemicals, Technology Classifications > Materials > Medical Devices > Diagnostic, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Reagents
Ait1 Protein to Control Eukaryote Metabolism
This invention provides compositions and methods for treating fungal or yeast infections using a previously unstudied GPCR-like protein which is integral to the regulation of cell growth in yeast cells. This protein and metabolic pathway is absent in higher-order animals, which provides a novel pathway for drugs to stop the growth of deadly fungal...
Published: 4/26/2021   |   Inventor(s): Andrew Capaldi, Ryan Wallace, Eric Lu
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Protein, Technology Classifications > Veterinary Medicine > Therapeutics & Vaccines, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Infectious Diseases
Protein Structure Analysis using One-Step Tyrosine Conjugation
This invention includes methods and systems for detecting, comparing, or evaluating proteins in an folded conformation, a particular bound state, or an aggregate state, and methods and systems for comparing amounts of labeling of a protein in a natural or control conformation and a denatured conformation. The methods of this invention may be used for...
Published: 12/2/2020   |   Inventor(s): Jacob Schwartz, John Jewett, Mahta Moinpour
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Category(s): Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Healthcare Portfolios > Orphan Diseases, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Protein
Biosensor for Detecting Structural Changes in Human Cardiac Muscle Protein
This technology is a biosensor that detects changes in phosphorylation of cardiac myosin-binding protein C (MyBP-C). Background: Heart disease is the leading cause of death globally. In the US, heart disease accounts for roughly a quarter of all deaths every year. One promising treatment for heart failure involves manipulation of phosphorylation states...
Published: 9/28/2020   |   Inventor(s): Brett Colson, Rhye-Samuel Kanassatega
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools, Technology Classifications > Life Sciences
Small Molecule Scaffolds for use as Protein Tags, Probes, and Conjugates
This invention relates to a molecular delivery system containing a chemical scaffold based on triazabutadiene, which can release a chemical species containing (a) a reactive diazaonium functional group covalently linked to (b) any number of aryl groups using a simple Suzuki coupling. The chemical species so released may be a drug, probe, tag, or conjugate....
Published: 7/1/2020   |   Inventor(s): Abigail Shepard, John Jewett
Keywords(s):  
Category(s): Technology Classifications > Materials > Chemicals, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Protein, Technology Classifications > Research Tools > Reagents, Technology Classifications > Research Tools > Screening assays
Shelf-Stable Reagent for Bioconjugation and Protein Labeling
This invention is a new class of amine-reactive, water-stable, small molecules for use as probes, reagents, or bioconjugates. These molecules are lysine-reactive and conjugate quickly without the need for coupling reagents or catalysts. The molecules are simple to synthesize and purify, with high yields. These materials selectively react with lysine...
Published: 3/17/2020   |   Inventor(s): John Jewett, Garrett Davis, Holly Sofka
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Protein, Technology Classifications > Research Tools > Reagents, Technology Classifications > Life Sciences > Diagnostics
Packed Bed Scintillation Particles for Radioisotope Detection and Separations
University of Arizona researchers have developed hydrophilic scintillation microparticles made with polystyrene cores, doped with a scintillator material, and encapsulated with a thin silica coating. The resulting microparticles are hydrophilic and can be easily surface modified to provide a variety of purposes in radioisotope activity detection, such...
Published: 2/7/2020   |   Inventor(s): Craig Aspinwall, Minhui Han, Colleen Janczak
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Category(s): Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation > Microfluidics, Technology Classifications > Materials > Chemicals, Technology Classifications > Materials > Nanomaterials, Technology Classifications > Research Tools > Protein, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Sensors & Controls > Particle & Radiation
Fluorescent Protein Biosensors for High-Throughput Drug Discovery
This technology involves biosensors for drug discovery that can be used in a high-throughput assay to detect the properties of actin-binding proteins using a fluorescence lifetime plate reader. Background: On average, someone dies of heart disease every 38 seconds and it is the leading cause of death in the U.S. University of Arizona inventors have...
Published: 12/10/2019   |   Inventor(s): Brett Colson
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Screening assays
Artificial Membranes Incorporating GPCRs for Label-Free, Electrophysiological Measurements of Ligand-GPCR Interactions
This invention consists of an artificial lipid membrane that incorporates G-protein coupled receptors into its structure. It allows direct, label-free measurement of ligand binding and activation of G-protein coupled receptors. Background: G-protein coupled receptors are a superfamily of proteins that are very popular drug targets. In 2017, 34%...
Published: 7/3/2019   |   Inventor(s): Steven Scott Saavedra, Craig Aspinwall
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Materials > Biomaterials, Technology Classifications > Research Tools > Screening assays
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