Search Results - technology+classifications+%3e+research+tools+%3e+protein

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Blood Biomarker for the Diagnosis and Treatment of Chronic Inflammation in the Brain in the Days and Weeks after Stroke
This invention comprises a method of identifying chronic inflammation in the day(s), weeks, or months after a stroke by measuring matrix metalloproteinase-12 (MMP-12) in a patient to determine whether therapeutic intervention is required to help immune cells process lipid debris after stroke to reduce secondary neurodegeneration. MMP-12 is a protein...
Published: 6/16/2021   |   Inventor(s): Kristian Doyle
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Research Tools > Protein
Ait1 Protein to Control Eukaryote Metabolism
This invention provides compositions and methods for treating fungal or yeast infections using a previously unstudied GPCR-like protein which is integral to the regulation of cell growth in yeast cells. This protein and metabolic pathway is absent in higher-order animals, which provides a novel pathway for drugs to stop the growth of deadly fungal...
Published: 4/26/2021   |   Inventor(s): Andrew Capaldi, Ryan Wallace, Eric Lu
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Protein, Technology Classifications > Veterinary Medicine > Therapeutics & Vaccines, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Infectious Diseases
Protein Structure Analysis using One-Step Tyrosine Conjugation
This invention includes methods and systems for detecting, comparing, or evaluating proteins in an folded conformation, a particular bound state, or an aggregate state, and methods and systems for comparing amounts of labeling of a protein in a natural or control conformation and a denatured conformation. The methods of this invention may be used for...
Published: 12/2/2020   |   Inventor(s): Jacob Schwartz, John Jewett, Mahta Moinpour
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Healthcare Portfolios > Orphan Diseases, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Protein
Small Molecule Scaffolds for use as Protein Tags, Probes, and Conjugates
This invention relates to a molecular delivery system containing a chemical scaffold based on triazabutadiene, which can release a chemical species containing (a) a reactive diazaonium functional group covalently linked to (b) any number of aryl groups using a simple Suzuki coupling. The chemical species so released may be a drug, probe, tag, or conjugate....
Published: 7/1/2020   |   Inventor(s): Abigail Shepard, John Jewett
Keywords(s):  
Category(s): Technology Classifications > Materials > Chemicals, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Protein, Technology Classifications > Research Tools > Reagents, Technology Classifications > Research Tools > Screening assays
Shelf-Stable Reagent for Bioconjugation and Protein Labeling
This invention is a new class of amine-reactive, water-stable, small molecules for use as probes, reagents, or bioconjugates. These molecules are lysine-reactive and conjugate quickly without the need for coupling reagents or catalysts. The molecules are simple to synthesize and purify, with high yields. These materials selectively react with lysine...
Published: 3/17/2020   |   Inventor(s): John Jewett, Garrett Davis, Holly Sofka
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Protein, Technology Classifications > Research Tools > Reagents, Technology Classifications > Life Sciences > Diagnostics
Design and Application of New Split-Luciferase Enzymes
UArizona researchers have developed a new split-firefly luciferase enzyme method for measuring protein-protein interactions for assays or sensors. This new method may, when combined with previous split luciferase methods, enable assays for two different protein interactions simultaneously, as well as provide a means for additional biophysical characterization....
Published: 3/9/2020   |   Inventor(s): Indraneel Ghosh, Matthew Bienick, Sean Campbell, Carl Buchholz
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Protein, Technology Classifications > Life Sciences
Automated Lipid Exchange-Mass Spectrometry System
This invention is an automated label-free method to measure the affinity of membrane proteins for lipids by using conventional small molecule mass spectrometry (MS) to monitor lipid exchange between lipoprotein nanoparticles called nanodiscs. We call this method lipid exchange-mass spectrometry (LX-MS). The concept is that if a membrane protein binds...
Published: 2/11/2020   |   Inventor(s): Michael Marty, James Keener, Guozhi Zhang
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Protein
Packed Bed Scintillation Particles for Radioisotope Detection and Separations
University of Arizona researchers have developed hydrophilic scintillation microparticles made with polystyrene cores, doped with a scintillator material, and encapsulated with a thin silica coating. The resulting microparticles are hydrophilic and can be easily surface modified to provide a variety of purposes in radioisotope activity detection, such...
Published: 2/7/2020   |   Inventor(s): Craig Aspinwall, Minhui Han, Colleen Janczak
Keywords(s):  
Category(s): Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation > Microfluidics, Technology Classifications > Materials > Chemicals, Technology Classifications > Materials > Nanomaterials, Technology Classifications > Research Tools > Protein, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Sensors & Controls > Particle & Radiation
Powdered G-protein Coupled Receptors
Inventors at the University of Arizona have generated G-protein coupled receptors (GPCRs) lypophilized (freeze-dried) into powdered form. When thawed and rehydrated, these GPCRs retain the functionality of their pre-frozen state even after one year. Because this process also involves the removal of water, the inventors were able to produce thawed GPCRs...
Published: 6/1/2016   |   Inventor(s): Michael Brown, Suchithranga Perera, Udeep Chawla
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Protein, Technology Classifications > Materials > Processing
Pseudoprolines in Neuropeptides
This invention describes the use of pseudo peptides to cross the blood-brain barrier and bind to targeted receptors to achieve pharmaceutical effects. Background: Increased research has led to the exploration of peptides delivering compounds by diffusing across the blood-brain barrier. Many peptide-based drugs are not created using pseudo-peptides,...
Published: 6/1/2016   |   Inventor(s): Robin Polt, Evan Jones
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Materials > Chemicals, Technology Classifications > Materials > Biomaterials, Technology Classifications > Research Tools > Protein, Technology Classifications > Materials > Medical Devices > Diagnostic, Technology Classifications > Materials > Medical Devices > Therapeutic
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